1361043-97-1

Basic information

• Product Name: ethyl 2-(4-(bis(1-ethyl-1H-indol-3-yl)methyl)phenoxy)acetate
• Synonyms: ethyl 2-(4-(bis(1-ethyl-1H-indol-3-yl)methyl)phenoxy)acetate
• CAS NO: 1361043-97-1
• Molecular Weight: 480.607
• Mol File: 1361043-97-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-(bis(1-ethyl-1H-indol-3-yl)methyl)phenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-(bis(1-ethyl-1H-indol-3-yl)methyl)phenoxy)acetate(1361043-97-1)
• EPA Substance Registry System: ethyl 2-(4-(bis(1-ethyl-1H-indol-3-yl)methyl)phenoxy)acetate(1361043-97-1)

Safety Data

• Hazardous Substances Data: 1361043-97-1(Hazardous Substances Data)

Upstream product

• 10604-59-8 N-Ethylindole 
• 51264-69-8 ethyl 2-(4-formylphenoxy)acetate 
• 120-72-9 indole 

Relevant articles and documents

Indole-based fibrates as potential hypolipidemic and antiobesity agents

Hypolipidemic and antiobesity effects of the newly synthesized indole-based fibrates were evaluated in Triton WR-1339 and high fat diet (HFD)-induced hyperlipidemic rats. Preliminary screening of all the synthesized compounds was done by using an acute model (Triton model), in which compounds 3f and 3l showed significant antidyslipidemic activity. Furthermore, these compounds 3f and 3l were found to induce significant weight loss in the visceral fat mass of HFD-fed hyperlipidemic rats without affecting the normal feeding behavior. Histological examination of the liver of rats supplemented with 3f and 3l revealed a significant decrease in steatosis when compared to the effect of the standard drug fenofibrate. Additional effects such as an increase in lecithin cholesterol acyl-transferase (LCAT) enzyme level and increased receptor mediated catabolism of I131-low density lipoproteins (LDL) confirm and reinforce the efficacy of both of these compounds as a new class of dual-acting hypolipidemic and antiobesity agents.