51264-69-8Relevant articles and documents
EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells
Jiang, Lijun,Lui, Yin-Lai,Li, Hongguang,Chan, Chi-Fai,Lan, Rongfeng,Chan, Wai-Lun,Lau, Terrence Chi-Kong,Tsao, George Sai-Wah,Mak, Nak-Ki,Wong, Ka-Leung
, p. 6517 - 6519 (2014)
An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected ca
PhotoTag: Photoactivatable Fluorophores for Protein Labeling
Fay, Rachael,Holland, Jason P.,Linden, Anthony
, (2020)
We report experimental studies on the development of photoactivatable fluorophores for rapid, light-induced synthesis of protein conjugates. Proof-of-concept studies demonstrated that electronic excitation of photoactivatable BODIPY-ArN3 (1) in
Synthesis and antinociceptive profile of novel acidic sulphonylhydrazone derivatives from natural safrole
Lima, Lidia M.,Amarante, Emanuel G.,Miranda, Ana L.P.,Fraga, Carlos A.M.,Barreiro, Eliezer J.
, p. 673 - 678 (1999)
The synthesis and antinociceptive activity of new sulphonylhydrazone derivatives is described. The synthetic route started from safrole, an abundant Brazilian natural product which occurs in sassafras oil (Ocotea pretiosa). The active compounds were obtai
Fluorescent multi-component polymer sensors for the sensitive and selective detection of Hg2+/Hg+ions: Via dual mode fluorescence and colorimetry
Cheng, Xinjian,Liu, Kaiqi,Marin, Luminita,Xiao, Li
, p. 22888 - 22901 (2021/12/24)
Multi-component polymers (MCPs) incorporate multiple components into the main chain or pendant group and have special functions. In this work, the small-molecule fluorescent boron-dipyrromethene (BODIPY), with ester groups and/or alkoxyl long chains, was synthesized first. Then, this small-molecule BODIPY and the components containing CC bonds (HD and PD) were reacted via the Heck coupling reaction to obtain macromolecular probes that perform different functions. With the help of ester groups and alkoxyl "tail", polymers MCP1 and MCP2 were soluble in a variety of water-miscible organic solvents. Moreover, MCP3 and MCP4 were completely soluble in water. These macromolecular probes showed sensitive and selective recognition toward Hg2+/Hg+ because of the introduced components (HD and PD) containing CC bonds. After binding to Hg2+/Hg+, MCP1 and MCP2 demonstrated fluorescence quenching and color changes, which allowed the dual-channel specific detection of Hg2+/Hg+. Compared with the probes containing HD, the probes containing PD showed higher sensitivity, and the good recognition ability caused the detection limit to be as low as 0.32 μM, which may be due to the "molecular wire"mechanism. The small-molecule components with different functional groups were polymerized into fluorescent polymer materials. This methodology endows the polymer probe with good solubility and high sensitivity, and the as-prepared polymers could sense metal ions in aqueous environments. This journal is
Acylhydrazone derivative containing phosphonate and preparation method and application thereof
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Paragraph 0024; 0026; 0027; 0028; 0029, (2020/03/12)
The invention discloses an acylhydrazone derivative containing phosphonate and a preparation method and application thereof. The structural general formula of the acylhydrazone derivative containing phosphonate is as shown in the specification. According