1361053-57-7Relevant academic research and scientific papers
Synthesis of macrocycles that inhibit protein synthesis: Stereochemistry and structural based studies on sanguinamide B derivatives
Pietkiewicz, Adrian L.,Wahyudi, Hendra,McConnell, Jeanette R.,McAlpine, Shelli R.
, p. 6979 - 6982 (2014)
We report the synthesis of seven new sanguinamide B (SanB) analogues. Substitution of amino acids along the backbone of SanB and testing in HCT-116 colon cancer cell lines identified new biologically active SanB derivatives. These compounds establish a st
Sanguinamide B analogs: Identification of active macrocyclic structures
Wahyudi, Hendra,Tantisantisom, Worawan,McAlpine, Shelli R.
supporting information, p. 2389 - 2393 (2014/05/06)
We report the synthesis of three new sanguinamide B (San B) analogs. We substituted in amino acids along the San B backbone with an N-Me, glycine, or an aromatic moiety (Phe or d-Phe) generating twelve derivatives in total. Testing in HCT-116 colon cancer
Total synthesis of trans, trans- Sanguinamide B and conformational isomers
Singh, Erinprit K.,Ramsey, Deborah M.,McAlpine, Shelli R.
supporting information; experimental part, p. 1198 - 1201 (2012/05/04)
The first total synthesis of Sanguinamide B is reported, prepared via an efficient synthetic strategy. The natural product, trans,trans-Sanguinamide B (1), was generated in a thermodynamic ratio with trans,cis-Sanguinamide B (2) and cis,cis-Sanguinamide B
