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Highly diastereo- and enantioselective Mannich reactions of synthetically flexible ketimines with secondary amine organocatalysts
Kano, Taichi,Song, Sunhwa,Kubota, Yasushi,Maruoka, Keiji
, p. 1191 - 1194 (2012/03/10)
High selectivity: A highly diastereo- and enantioselective Mannich reaction between a synthetically flexible ketimine and aldehydes has been developed. The syn- or anti-Mannich products contain tetrasubstituted chiral carbon centers and were obtained with almost complete stereoselectivity by using either L-proline or an axially chiral aminosulfonamide, respectively, as the catalyst (see scheme, Tf=trifluoromethanesulfonyl). Copyright
