1361058-62-9Relevant academic research and scientific papers
IRAK DEGRADERS AND USES THEREOF
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Paragraph 2313; 2314, (2019/07/10)
The present invention provides compounds, compositions thereof, and methods of using the same.
OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES
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Page/Page column 175, (2016/03/19)
Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.
Expanding the scope of silane-mediated hydrodehalogenation reactions
Noonan, Gary M.,Hayter, Barry R.,Campbell, Andrew D.,Gorman, Timothy W.,Partridge, Benjamin E.,Lamont, Gill M.
, p. 4518 - 4521 (2013/08/23)
A palladium-catalysed, silane-mediated hydrodehalogenation (HDH) reaction with increased substrate scope has been developed. Whereas previous attempts to reduce carboxylic acid or phenol-containing aryl halides using silane-based HDH conditions failed, the current protocol allows efficient access to the reduced products. Chemoselective HDH in the presence of sensitive functional groups is also presented.
An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]
Zhang, Dengyou,Sun, Haifeng,Zhang, Lei,Zhou, Yu,Li, Chunpu,Jiang, Hualiang,Chen, Kaixian,Liu, Hong
supporting information; experimental part, p. 2909 - 2911 (2012/03/27)
A practical Pd(PPh3)4/DBU catalytic system for the synthesis of pharmaceutically relevant aminopyridine nitrile intermediates, as well as a variety of other aryl nitriles using non-toxic K4[Fe(CN) 6] has been developed. The key features of our new protocol for cyanation lie in that the reaction can be carried out with readily available Pd(PPh3)4 under mild and green conditions, even without the assistance of other ligands. The Royal Society of Chemistry 2012.
