136106-08-6

Upstream product

• 108-89-4 picoline 
• 99-73-0 para-bromophenacyl bromide 

Downstream Products

• 838-32-4 2-(4-bromophenyl)-7-methylimidazo[1,2-a]pyridine 
• 255737-18-9 1-(4-bromophenacyl)-4-(trifluoroacetoxymercuriomethyl)pyridinium bromide 

Relevant academic research and scientific papers

Microwave-assisted, one-pot reaction of pyridines, -bromoketones and ammonium acetate: An efficient and simple synthesis of Imidazo[1,2- a ]-pyridines

A novel and efficient synthesis of imidazo[1,2-a]pyridines is described. N-Phenacylpyridinium bromides, which were prepared in situ from the addition of pyridines to -bromoketones, undergo nucleophilic addition of ammonium acetate under microwave irradiation and solvent-free conditions to afford the corresponding imidazo[1,2-a]pyridines in excellent yields.

Discovery of indolizines containing triazine moiety as new leads for the development of antitumoral agents targeting mitotic events

Abstract A new family of 3-aroylindolizines bearing a dimethoxytriazine unit in their position 1 was designed, synthesized and evaluated for their ability to inhibit tubulin polymerization and cellular growth in vitro. Compound 39 was the best candidate i

Synthesis and biological evaluation of some new indolizine derivatives as antitumoral agents

A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS c

Synthesis and biological evaluation of some new indolizine derivatives as antitumoral agents

A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS c

Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase

The rational structural modification of new substituted indolizin-3-yl(phenyl)methanones 1a-i, 2a-i and 3a-i has greatly improved human farnesyltransferase inhibition. The para-bromophenyl analog 2f bearing an ester unit on the indolizine ring demonstrates the highest inhibition potential, with IC50 value of 1.3 ± 0.2 μM. The amidic series 1a-i proves to be the most promising for future modulations, particularly at the triple bond level.

Microwave-assisted, one-pot three component synthesis of 2-phenyl H-imidazo[1, 2-α]pyridine

A novel synthesis of 2-phenylH-imidazio[1, 2-α] pyridines is described from a one-pot, three-component reaction between pyridine, guanidine (urea or thiourea) and α-bromoketones under microwave irradiation and solvent-free conditions in excellent yields.

Efficient synthesis of 6a-azonia[5]helicene salts utilizing steric interactions of substituents

The synthesis of a series of substituted 6a-azonia[5]helicene salts 3d-j and 12a-azoniabenzo[ghi]perylene salts 4d and 4g by photocyclization of the corresponding 2-styrylbenzo[a]-quinolizinium derivatives 2d-j is described. The product ratios of 3d-j and

The Mechanism of Alkylation Reactions. Part 2. The Effect of Pressure and Substituents on the Reaction of Phenacyl Bromide with Pyridine in Methanol

Rate constants have been determined for the reaction of p-bromophenacyl bromide with pyridine and three substituents pyridines in methanol at 313.2 K.The reaction of phenacyl bromide in methanol at 313.2 K was investigated for pressures up to 100 MPa and the effect of substituents on the volume of activation, ΔV*, determined.From the partial molar volumes of reactants and products, the values of ΔV* were interpreted in terms of the intrinsic volume of the transition state, solvent electrostriction in the transition state and differences in hydrogen bonding between the initial and the transition state.The results support a transition state in which (a) bond forming leads over bond breaking and (b) considerable charge dispersal occurs.A priori calculations of ΔV and ΔV* are compared with experimental values and their utility discussed.