136106-09-7Relevant academic research and scientific papers
Efficient synthesis of indolizines and new imidazo[1,2-a]pyridines via the expected cyclization of aromatic cycloimmonium ylides with electron deficient alkynes and ethyl cyanoformate
Sandeep,Padmashali, Basavaraj,Kulkarni, Rashmi S.
, p. 6411 - 6414 (2013)
Aromatic cycloimmonium ylides underwent smooth cyclization with electron deficient alkynes in presence of anhydrous K2CO3 in DMF solvent at room temperature to afford substituted indolizines. Ylides have also undergone expected cyclization with ethyl cyanoformate to produce imidazo[1,2-a]pyridines. The structures of these newly synthesized compounds have been confirmed by spectroscopic techniques and X-ray diffraction studies.
The Mechanism of Alkylation Reactions. Part 2. The Effect of Pressure and Substituents on the Reaction of Phenacyl Bromide with Pyridine in Methanol
Forster, William,Laird, Robert M.
, p. 1033 - 1044 (2007/10/02)
Rate constants have been determined for the reaction of p-bromophenacyl bromide with pyridine and three substituents pyridines in methanol at 313.2 K.The reaction of phenacyl bromide in methanol at 313.2 K was investigated for pressures up to 100 MPa and the effect of substituents on the volume of activation, ΔV*, determined.From the partial molar volumes of reactants and products, the values of ΔV* were interpreted in terms of the intrinsic volume of the transition state, solvent electrostriction in the transition state and differences in hydrogen bonding between the initial and the transition state.The results support a transition state in which (a) bond forming leads over bond breaking and (b) considerable charge dispersal occurs.A priori calculations of ΔV and ΔV* are compared with experimental values and their utility discussed.
