136112-75-9

Usage

Uses

Used in Pharmaceutical Industry:
Przewalskinic acid A is used as a potential anti-tumor agent for its demonstrated effects against certain types of cancer. Although more research is needed to fully understand its potential in this area, it has shown promise in preliminary studies.
Used in Neurodegenerative Disease Treatment:
Przewalskinic acid A is used as a neuroprotective agent, with significant effects that could be beneficial in the treatment of neurodegenerative diseases. Its neuroprotective properties make it a valuable resource for further exploration in this field.

Upstream product

• 1609691-94-2 (2S,3R)-2-{3,4-bis(triisopropylsilyloxy)phenyl}-7-(methoxymethoxy)-2,3-dihydrobenzofuran-3-carboxylic acid 
• 1609691-96-4 (2S,3R)-2-{3,4-bis(triisopropylsilyloxy)phenyl}-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylic acid 
• 1609691-97-5 (2S,3R)-2-{3,4-bis(triisopropylsilyloxy)phenyl}-7-hydroxy-4-{(E)-3-oxo-3-(2,2,2-trichloroethoxy)prop-1-en-1-yl}-2,3-dihydrobenzofuran-3-carboxylic acid 
• 1609692-00-3 C₃₆H₅₄O₈Si₂ 
• 1126-20-1 2-allyloxyphenol 
• 115939-25-8 salvianolic acid B 
• 1609691-88-4 (2S,3R)-allyl 2-{3,4-bis(triisopropylsilyloxy)phenyl}-7-(methoxymethoxy)-2,3-dihydrobenzofuran-3-carboxylate 
• 1609691-89-5 allyl 2-[2-{3,4-bis(triisopropylsilyloxy)benzyloxy}-3-(methoxymethoxy)phenyl]-2-diazo acetate 
• 1609691-99-7 C₄₅H₆₆O₈Si₂ 
• 1609691-93-1 allyl 2-[2-{3,4-bis(triisopropylsilyloxy)benzyloxy}-3-(methoxymethoxy)phenyl]acetate 
• 1609691-92-0 2-[2-{3,4-bis(triisopropylsilyloxy)benzyloxy}-3-(methoxymethoxy)phenyl]acetic acid 
• 1609691-91-9 1-allyl-3-(methoxymethoxy)-2-[3,4-bis(triisopropylsilyloxy)benzyloxy]benzene 
• 1609691-90-8 2-allyl-6-(methoxymethoxy)phenol 
• 1609691-98-6 1-allyloxy-2-(methoxymethoxy)benzene 

Relevant academic research and scientific papers

Sebestenoids A-D, BACE1 inhibitors from Cordia sebestena

Bioassay-guided fractionation of an extract prepared from the fruits of Cordia sebestena led to the isolation of sebestenoids A-D (1-4). Their structures were elucidated on the basis of extensive NMR experiments and mass spectroscopic measurements. Compounds 1-4 exhibited moderate inhibition of the aspartic protease BACE1.

Stereoselective phenolic coupling in Blechnum spicant: Formation of 8-2′ linked (-)-cis-blechnic, (-)-trans-blechnic and (-)-brainic acids

In vivo administration experiments using stable (13C) and radio (14C) labeled precursors provide further evidence for vascular plant proteins engendering specific but distinct phenolic coupling modes, i.e. in this case for stereosele

Degradation kinetics and mechanism of lithospermic acid under low oxygen condition using quantitative 1H NMR with HPLC-MS

A novel quantitative 1H NMR (Q-NMR) combined with HPLC-MS method has been pro posed for investigating the degradation process of traditional Chinese medicine (TCM) components. Through this method, in-situ monitoring of dynamics degradation proc

Asymmetric Total Synthesis of (-)- trans -Blechnic Acid via Rhodium(II)-Catalyzed C-H Insertion and Palladium(II)-Catalyzed C-H Olefination Reactions

An asymmetric total synthesis of (-)-trans-blechnic acid, a dihydrobenzofuran neolignan, has been achieved. The key steps involve an elaboration of the cis-2,3-dihydrobenzofuran core structure by enantio- and diastereoselective intramolecular C-H insertion using dirhodium(II) tetrakis[N-phthaloyl-(R)-tert-leucinate] [Rh2(R-PTTL)4] and a direct coupling of an acrylate unit with the core structure employing Yu's palladium(II)-catalyzed intermolecular C-H olefination. Georg Thieme Verlag Stuttgart, New York.

Diastereomers of lithospermic acid and lithospermic acid B from Monarda fistulosa and Lithospermum erythrorhizon

Monardic acids A (1) and B (2), which are (7R,8R) diastereomers of lithospermic acid (LA) and lithospermic acid B, respectively, were isolated from Monarda fistulosa. A (7S,8R) isomer (3) of LA was also isolated from this plant, and a (7R,8S) isomer (7) of LA was obtained from Lithospermum erythrorhizon. The absolute configuration of 1 was confirmed by analysis of its hydrolysates, 7-epiblechnic acid and 2R-3-(3,4-dihydroxyphenyl)-2- hydroxypropanoic acid. The configuration in the dihydrobenzofuran moieties of 2, 3, and 7 was extrapolated by using the phenylglycine methyl ester method and a Cotton effect at approximately 250-260 nm in their electronic circular dichroism spectra. Diastereomers (1-3 and 7) displayed moderate hyaluronidase inhibitory and histamine release inhibitory activities.

Derivatives of 8-epiblechnic Acid and their Effects on Down-Regulation of Endothelin (ETA) receptor mRNA

The present application discloses derivatives of 8-epiblechnic acid and use thereof in treating a disease related to endothelin receptor A or endothelin-1 (ET-1) over-expression, such as hypertension, cancer, atherosclerosis, and myocardial infarction.

Chemical and chemotaxonomical studies of ferns. LXXXI. Characteristic lignans of blechnaceous ferns

Four lignans, blechnic acid (1), 7-epiblechnic acid (3), 8-epiblechnic acid (6) and brainic acid (2), were isolated from six Blechnaceous ferns, Blechnum orientale, Struthiopteris amabilis, S. niponica, Woodwardia orientalis, W. proilfera and Brainea insignis. Their structures were determined by spectroscopic methods and chemical conversion.