136117-83-4 Usage
Explanation
The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 11 carbon (C) atoms, 10 hydrogen (H) atoms, 2 nitrogen (N) atoms, and 1 oxygen (O) atom.
Explanation
The compound features an imidazo[1,2-a]pyridine ring system, which is a fused ring structure consisting of an imidazole and a pyridine. This ring system is commonly found in many pharmaceutical drugs.
Explanation
The compound contains a ketone functional group, which is a carbonyl group (C=O) bonded to two carbon atoms. In this case, the ketone group is attached to a propyl chain.
Explanation
Due to its unique structure and functionality, 1-(Imidazo[1,2-a]pyridin-3-yl)propan-2-one is utilized in the development of potential pharmaceutical agents, particularly in medicinal chemistry and drug discovery.
Explanation
The compound is often used as a building block in organic synthesis, allowing chemists to create more complex molecules by attaching other functional groups or modifying the existing structure.
Explanation
The specific properties and potential applications of 1-(Imidazo[1,2-a]pyridin-3-yl)propan-2-one depend on its structure and functionality, making it an important compound in the field of medicinal chemistry and drug discovery.
Structure
Imidazo[1,2-a]pyridine ring system
Functional Group
Ketone (propan-2-one)
Pharmaceutical Applications
Potential development of pharmaceutical agents
Organic Synthesis
Building block
Importance
Structure and functionality
Check Digit Verification of cas no
The CAS Registry Mumber 136117-83-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,1,1 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 136117-83:
(8*1)+(7*3)+(6*6)+(5*1)+(4*1)+(3*7)+(2*8)+(1*3)=114
114 % 10 = 4
So 136117-83-4 is a valid CAS Registry Number.
136117-83-4Relevant academic research and scientific papers
Imidazo[1,2-a]pyridines. Synthesis and inotropic activity of new 5-imidazo[1,2-a]pyridinyl-2(1H)-pyridinone derivatives
Yamanaka,Miyake,Suda,Ohhara,Ogawa
, p. 1556 - 1567 (2007/10/02)
A series of 1,2-dihydro-5-imidazo[1,2-a]pyridinyl-2(1H)-pyridinones was synthesized and evaluated for positive inotropic activity. 1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3- pyridinecarbonitrile (11a) hydrochloride monohydrate (E-1020) was found to be a potent and selective inhibitor of phosphodiesterase III and a long-acting, potent, orally active positive inotropic agent. Additional imidazo[1,2-a]pyridin-2-yl (3a), -3-yl (16), -7-yl (20) and -8-yl (24a) compounds were also prepared. Altering the pyridine substitution from the 2-position to the 6-position produced a 2-fold increase in the i.v. cardiotonic potency (ED50) from 52 to 23 μg/kg, while substitution at the 3-, 7- or 8-position reduced potency. In the 2-positional isomers, introduction of halogen groups enhanced the activity and 3-chloro-1,2-dihydro-5-(6-fluoroimidazo[1,2-a]pyridin-2-yl)-6-methyl-2(1H)- pyridinone (3a) was the most potent (i.v. ED50 11 μg/kg) in this seris. E-1020 is presently under development for the treatment of congestive heart failure.
