4926-47-0

Basic information

• Product Name: 3-BROMOIMIDAZO[1,2-A]PYRIDINE
• Synonyms: 3-BROMOIMIDAZO[1,2-A]PYRIDINE;BUTTPARK 96\50-11;3-Bromoimidazo[1,2-a]pyridine, 95+%;3-Bromopyrimidazole;Imidazo[1,2-a]pyridine, 3-bromo- (7CI,8CI,9CI);NSC 305197;IMidazo[1,2-a]pyridine, 3-broMo-;3-Bromoimidazo[1,2-a]pyridine 97%
• CAS NO: 4926-47-0
• Molecular Formula: C₇H₅BrN₂
• Molecular Weight: 197.03
• Product Categories: Halides;Fused Ring Systems;Imidazopyridines;Building Blocks;C7 to C18;C7 to C8;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines
• Mol File: 4926-47-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 92 °C
• Appearance: /
• Density: 1.69 g/cm³
• Refractive Index: 1.688
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.85±0.50(Predicted)
• CAS DataBase Reference: 3-BROMOIMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMOIMIDAZO[1,2-A]PYRIDINE(4926-47-0)
• EPA Substance Registry System: 3-BROMOIMIDAZO[1,2-A]PYRIDINE(4926-47-0)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 20/21/22-22
• Safety Statements: 22-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 4926-47-0(Hazardous Substances Data)

Usage

General Description

3-Bromoimidazo[1,2-a]pyridine is a chemical compound with the formula C6H4BrN3. It is a heterocyclic compound containing a pyridine ring fused to an imidazole ring, with a bromine atom attached to the imidazole ring. 3-BROMOIMIDAZO[1,2-A]PYRIDINE is used as a building block in organic synthesis, particularly in the pharmaceutical industry for the production of various drugs and drug candidates. It has been utilized in the development of potential treatments for diseases such as cancer, Alzheimer's, and schizophrenia. Additionally, 3-Bromoimidazo[1,2-a]pyridine has also found applications in the field of materials science for the synthesis of organic semiconductors and in the production of agrochemicals. Due to its versatile reactivity and wide range of applications, this compound is of significant interest to researchers and industry professionals.

InChI:InChI=1/C7H5BrN2/c8-6-5-9-7-3-1-2-4-10(6)7/h1-5H

Upstream product

• 504-29-0 2-aminopyridine 
• 274-76-0 imidazo[1,2-a]pyridine 

Downstream Products

• 1042224-71-4 C₁₂H₈BrN₃ 
• 17745-04-9 imidazo<1,2-a>pyridin-3-acetic acid 
• 274-76-0 imidazo[1,2-a]pyridine 
• 943320-53-4 3-acetylenylimidazo[1,2-a]pyridine 
• 860257-98-3 N-imidazo[1,2-a]pyridin-3-yl-benzamide 
• 1345964-69-3 imidazo[1,2-a]pyridin-3-yldiphenylmethanol 
• 1195383-70-0 3-(4-benzyloxy-3-methoxyphenyl)imidazo[1,2-a]pyridine 
• 1246184-48-4 N-(2-chloro-5-(imidazo[1,2-a]pyridin-3-yl)pyridin-3-yl)-bis(4-fluorobenzenesulfonamide) 
• 1246184-23-5 4-fluoro-N-(5-imidazo[1,2-a]pyridin-3-yl-3-pyridinyl)benzenesulfonamide 
• 1195386-69-6 3-(4-hydroxy-3-methoxyphenyl)imidazo[1,2-a]pyridine 

Relevant articles and documents

Electrochemical C-H Halogenations of Enaminones and Electron-Rich Arenes with Sodium Halide (NaX) as Halogen Source for the Synthesis of 3-Halochromones and Haloarenes

Without employing an external oxidant, the simple synthesis of 3-halochromones and various halogenated electron-rich arenes has been realized with electrode oxidation by employing the simplest sodium halide (NaX, X = Cl, Br, I) as halogen source. This electrochemical method is advantageous for the simple and mild room temperature operation, environmental friendliness as well as broad substrate scope in both C-H bond donor and halogen source components.

Sodium Salts (NaI/NaBr/NaCl) for the Halogenation of Imidazo-Fused Heterocycles

We report herein an effective method for the halogenation of imidazo-fused heterocycles using readily available sodium salts (NaCl/NaBr/NaI) as halogen source and K2S2O8 (or) oxone as promoter. A variety of C-3 halogenated imidazo[1,2-a]pyridines and benzo[d]imidazo[2,1-b]thiazoles were obtained in good to excellent yields. The present method of halogenation has been also extended to 2-aminopyridines, 2-aminopyrimidine, indole, and isoquinoline with moderate to excellent yields.

Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor

The discovery and characterization of a novel chemical series of phosphorothioyl-containing imidazopyridines as potent neuropeptide S receptor antagonists is presented. The synthesis of analogues and their structure-activity relationship with respect to the Gq, Gs, and ERK pathways is detailed. The pharmacokinetics and in vivo efficacy of a potent analogue in a food intake rodent model are also included, underscoring its potential therapeutic value for the treatment of sleep, anxiety, and addiction disorders. This article not subject to U.S. Copyright. Published 2013 by the American Chemical Society.