1361190-50-2Relevant academic research and scientific papers
Cu(I)-Catalyzed gem-Aminoalkynylation of Diazo Compounds: Synthesis of Fluorinated Propargylic Amines
Pisella, Guillaume,Ramirez, Nieves P.,Waser, Jerome
supporting information, p. 10928 - 10938 (2021/07/31)
The gem-aminoalkynylation of fluorinated diazo compounds catalyzed by a simple Cu(I) salt is described. This three-component reaction allows the synthesis of propargylic amines with broad functional group tolerance. Both electron-rich and electron-poor an
Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation
Chen, Mu-Wang,Wu, Bo,Chen, Zhang-Pei,Shi, Lei,Zhou, Yong-Gui
, p. 4650 - 4653 (2016/09/28)
A highly enantioselective synthesis of chiral fluorinated propargylamines was developed through phosphoric acid and ruthenium-catalyzed chemoselective biomimetic hydrogenation of the carbon-nitrogen double bond of fluorinated alkynyl ketimines in the presence of a carbon-carbon triple bond. This reaction features high chemoselectivity and slow background reaction. In addition, selective transformations of the chiral fluorinated propargylamines were also reported.
