1361215-97-5

Upstream product

• 71-43-2 benzene 
• 624-28-2 2,5-dibromopyridine 
• 1361215-96-4 4,4,5,5-tetramethyl-2-(4-(phenylsulfonyl)phenyl)-1,3,2-dioxaborolane 
• 23038-36-0 1-bromo-4-(phenylsulphonyl)benzene 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 14774-79-9 1-iodo-4-(phenylsulfonyl)benzene 
• 611168-46-8 5-bromo-2-(tri-n-butylstannyl)pyridine 

Downstream Products

• 1361215-95-3 1,1,1,3,3,3-hexafluoro-2-(6-(4-(phenylsulfonyl)phenyl)-3-pyridinyl)-2-propanol 

Relevant academic research and scientific papers

Enhancing the electroluminescence performances of novel platinum(II) polymetallayne-based phosphorescent polymers through employing functionalized IrIII phosphorescent units and facilitating triplet energy transfer

Novel orange phosphorescent polymers with platinum(ii) polymetallayne-based backbones have been successfully developed through Sonogashira cross-coupling among bicarbazole moieties, functionalized IrIII phosphorescent blocks with electron injection/transporting (EI/ET) features, and trans-[PtCl2(PBu3)2]. Importantly, the very efficient energy-transfer process is observed from the triplet states of the polymetallayne-based backbone to the triplet metal-to-ligand charge transfer states (3MLCT) of the phosphorescent units in the polymer backbone, which will guarantee the high phosphorescent ability of these polymers. Benefiting from the weak conjugation-extending ability of the platinum(II) ions, the polymetallayne-based backbones show high triplet energy-level to effectively block the undesired reverse energy-transfer process. Furthermore, the EI/ET features of the functionalized IrIII phosphorescent units should balance the hole injection/transporting (HI/HT) of the bicarbazole moieties to improve the EL performances of these phosphorescent polymers. Benefiting from these merits, the phosphorescent polymers can furnish solution-processed phosphorescent OLEDs (PHOLEDs) with high EL efficiencies with current efficiency (ηL) of 9.17 cd A-1, external quantum efficiency (ηext) of 4.50% and power efficiency (ηP) of 4.04 lm W-1, representing very decent electroluminescent performances achieved by the orange phosphorescent polymers. This work herein might not only show the great potential of platinum(II) polymetallayne as the host segments in phosphorescent polymers, but also provide a new outlet to design and synthesise highly efficient phosphorescent copolymers.

SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES

The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.