14774-79-9

Basic information

• Product Name: 1-iodo-4-(phenylsulfonyl)benzene
• CAS NO: 14774-79-9
• Molecular Formula: C₁₂H₉IO₂S
• Molecular Weight: 344.1681
• Mol File: 14774-79-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 433.9°C at 760 mmHg
• Flash Point: 216.2°C
• Density: 1.721g/cm³
• Vapor Pressure: 2.51E-07mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: 1-iodo-4-(phenylsulfonyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-iodo-4-(phenylsulfonyl)benzene(14774-79-9)
• EPA Substance Registry System: 1-iodo-4-(phenylsulfonyl)benzene(14774-79-9)

Safety Data

• Hazardous Substances Data: 14774-79-9(Hazardous Substances Data)

Usage

Physical state

White to off-white solid

Uses

Pharmaceutical intermediate, organic synthesis (as a halogenating agent), production of dyes and pigments

Chemical properties

Strong electronegative iodine atom, phenylsulfonyl group

Safety precautions

Handle with care due to toxic and irritant properties

Upstream product

• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 133745-75-2 N-fluorobis(benzenesulfon)imide 
• 873-55-2 sodium benzenesulfonate 
• 1514-50-7 4-iodobenzenediazonium tetrafluoroborate 
• 589-87-7 1,4-bromoiodobenzene 
• 7019-01-4 p-aminophenyl phenyl sulfone 
• 1146-39-0 4-nitrophenyl phenyl sulfone 
• 350-46-9 4-Fluoronitrobenzene 
• 98-09-9 benzenesulfonyl chloride 
• 7446-70-0 aluminium trichloride 
• 98-61-3 p-Iodobenzenesulfonyl chloride 
• 71-43-2 benzene 
• 40915-22-8 4,4'-diiododiphenyl sulfone 

Downstream Products

• 872264-83-0 (4-iodosyl-phenyl)-phenyl sulfone 
• 1361215-97-5 5-bromo-2-(4-(phenylsulfonyl)phenyl)pyridine 

Relevant articles and documents

Metal-free sulfonylation of arenes with: N -fluorobenzenesulfonimide via cleavage of S-N bonds: expeditious synthesis of diarylsulfones

A novel metal-free sulfonylation of arenes with N-fluorobenzenesulfonimide (NFSI) toward the synthesis of diarylsulfones has been developed. The reaction represents a rare example of sulfonylation reaction using NFSI as an efficient sulfonyl donor and the first example of acid-mediated sulfonylation of unactivated arenes with NFSI via selective cleavage of S-N bonds. This protocol provides a concise approach for the construction of pharmaceutically and biologically important diarylsulfones. Applications in the functionalization of natural products (e.g., β-estradiol) and in the synthesis of a key intermediate to an inhibitor of farnesyl-protein transferase, as well as in the gram-scale synthesis of the EPAC2 antagonist, are demonstrated. This journal is

Synthesis method of diaryl sulfone compound (by machine translation)

The invention discloses a synthesis method of a diaryl sulfone compound, wherein the, reaction equation of the series of N - diarylsulfone compounds is prepared by (NFSI) sulfonylating the aromatic hydrocarbon under the non-metal condition with the source of the, benzenesulfonyl group as the benzenesulfonyl group, and: the reaction equation is as follows. STR3, #, STR2, #, STR2, #, #, #, # STR2. # STR2# STR2# STR2, , STR2 STR2 STR2 N - # (NFSI) STR2# STR2 STR2 STR2, #, # STR1 STR8# STR2 STR1 STR8. AlCl R3 , FeCl3 The other precious, and metals of, other metals such as the precious metals of, the other noble metals not cause the environment, to pollute, the environment and are suitable for the concise and high-efficiency synthesis of. the diarylsulfone compounds, and have good application prospects in the fields of organic synthesis, drug research and development and the like. (by machine translation)