1361234-38-9

Basic information

• Product Name: methyl 4-bromo-N-cyano-2-nitrobenzimidate
• CAS NO: 1361234-38-9
• Molecular Weight: 284.069
• Mol File: 1361234-38-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4-bromo-N-cyano-2-nitrobenzimidate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-bromo-N-cyano-2-nitrobenzimidate(1361234-38-9)
• EPA Substance Registry System: methyl 4-bromo-N-cyano-2-nitrobenzimidate(1361234-38-9)

Safety Data

• Hazardous Substances Data: 1361234-38-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 420-04-2 CYANAMID 
• 5551-12-2 4-bromo-2-nitrobenzaldehyde 

Relevant articles and documents

Synthesis of 2,4-diaminoquinazolines and tricyclic quinazolines by cascade reductive cyclization of methyl N -cyano-2-nitrobenzimidates

An efficient route to N4-substituted 2,4-diaminoquinazolines has been developed by employing tandem condensation of cyanoimidate-amine and reductive cyclization in iron-HCl system. This method is tolerant of a following intramolecular N-alkylation and produces two fused heterocycles in a one-pot procedure. This protocol is a facile two-step synthesis of tricyclic quinazolines, which is effected by potent cyanoimidation and tandem reductive cyclization from 2-nitrobenzaldehydes. Moreover, the forming process of tricyclic quinazolines has been investigated from the ring-opening/ring-closing cascade point of view. It is found that the preparation of tricyclic quinazolinones in good yields relies on the selective hydrolysis of tricyclic quinazolines in base or acid system.