1361249-52-6

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 1004904-88-4 (S)-2-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)1-tert-butyl pyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1361249-09-3 [(1S)-2-methyl-1-[[(2S)-2-[5-(1,1′-biphenyl)-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]propyl]carbamic acid methyl ester 
• 1426938-56-8 C₂₆H₂₈N₄O₂ 
• 1426938-55-7 C₂₇H₃₂N₄O₃ 
• 1361249-11-7 C₂₇H₃₂N₄O₃ 

Relevant academic research and scientific papers

Water enables an asymmetric cross reaction of α-keto acids with α-keto esters for the synthesis of quaternary isotetronic acids

A water promoted asymmetric aldol/lactonization/enolization cascade reaction of α-keto acids and α-keto esters was developed, affording the first general protocol for the construction of chiral quaternary isotetronic acids with excellent enantioselectivity. Theoretical results indicate that intramolecular ionized enamine intermediates stabilized by water generate zwitterionic transition states in a lower activation energy and higher face selectivity, resulting in high activity and chemo- and enantioselectivity.

Chiral catalyst suitable for water-oil two-phase system and preparation and application thereof

The invention relates to preparation and application of a chiral catalyst suitable for a water-oil two-phase system. The structure of the catalyst is shown in the description. The design of the catalyst is characterized in that L-proline protected by Boc is taken as a precursor for constructing a chiral imidazole proline derivative, and then radicals of R1 and R2 of the structure are adjusted to change the spatial three-dimensional structure and electronic effect of the catalyst, so that the aim of performing chiral adjustment on a reaction is fulfilled. The catalyst is easy and convenient to operate and is practical and feasible, the catalyst precursor and raw materials used in the reaction are commercially available, and reaction conditions are mild. The catalyst can substitute for a noble metal for conventional metal organic catalysis, can be applied to catalysis of an Aldol reaction of the water-oil two-phase system, has high enantioselectivity and high yield, is environmentally friendly, and shows superior catalyzing performance compatible with a water phase and an oil phase as well as a potential commercial value.

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors

Based on the symmetrical bidentate structure of the NS5A inhibitor BMS-790052, a series of new monodentate molecules were designed. The synthesis of 36 new non-dimeric NS5A inhibitors is reported along with their ability to block HCV replication in an HCV 1b replicon system. Among them compound 5a showed picomolar range activity along with an excellent selectivity index (SI > 90,000).

POTENT AND SELECTIVE INHIBITORS OF HEPATITIS C VIRUS

The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs, and othe