1361322-92-0

Basic information

• Product Name: (S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)pyrrolidine-1-carboxylate hydrochloride
• Synonyms: (S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)pyrrolidine-1-carboxylate hydrochloride
• CAS NO: 1361322-92-0
• Molecular Weight: 395.93
• Mol File: 1361322-92-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)pyrrolidine-1-carboxylate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)pyrrolidine-1-carboxylate hydrochloride(1361322-92-0)
• EPA Substance Registry System: (S)-benzyl 3-((S)-2-amino-2-cyclohexylacetamido)pyrrolidine-1-carboxylate hydrochloride(1361322-92-0)

Safety Data

• Hazardous Substances Data: 1361322-92-0(Hazardous Substances Data)

Upstream product

• 122536-74-7 (S)-3-<<(1,1-dimethylethoxy)carbonyl>amino>-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 501-53-1 benzyl chloroformate 
• 1361322-91-9 (S)-benzyl 3-((S)-2-(tert-butoxycarbonylamino)-2-cyclohexylacetamido)pyrrolidine-1-carboxylate 
• 550378-39-7 (S)-benzyl 3-aminopyrrolidine-1-carboxylate hydrochloride 

Downstream Products

• 1361322-94-2 tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-pyrrolidin-3-ylamino)ethylamino)-1-oxopropan-2-yl(methyl)carbamate 
• 1361322-42-0 (S)-N-((S)-2-((S)-1-benzylpyrrolidin-3-ylamino)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide 
• 1361322-44-2 (S)-N-((S)-1-cyclohexyl-2-oxo-2-((S)-1-phenethylpyrrolidin-3-ylamino)ethyl)-2-(methylamino)propanamide 
• 1361322-45-3 (S)-N-((S)-1-cyclohexyl-2-oxo-2-((S)-1-(3-phenylpropyl)pyrrolidin-3-ylamino)ethyl)-2-(methylamino)propanamide 
• 1361322-95-3 tert-butyl (S)-1-((S)-2-((S)-1-benzoylpyrrolidin-3-ylamino)-1-cyclohexyl-2-oxoethylamino)-1-oxopropan-2-yl(methyl)carbamate 
• 1361322-96-4 tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-1-(2-phenylacetyl)pyrrolidin-3-ylamino)ethylamino)-1-oxopropan-2-yl(methyl)carbamate 
• 1361322-93-1 (S)-benzyl 3-((S)-2-((S)-2-(tert-butoxycarbonyl(methyl)amino)propanamido)-2-cyclohexylacetamido)pyrrolidine-1-carboxylate 

Relevant articles and documents

Discovery of aminopiperidine-based Smac mimetics as IAP antagonists

A series of structurally unique Smac mimetics that act as antagonists of inhibitor of apoptosis proteins (IAPs) has been discovered. While most previously described Smac mimetics contain the proline ring (or a similar cyclic motif) found in Smac, a key feature of the compounds described herein is that this ring has been removed. Despite this, compounds in this series potently bind to cIAP1 and elicit the expected phenotype of cIAP1 inhibition in cancer cells. Marked selectivity for cIAP1 over XIAP is observed for these compounds, which is attributed to a slight difference in the binding groove between the two proteins and the resulting steric interactions with the inhibitors. XIAP binding can be improved by constraining the inhibitor so that these unfavorable steric interactions are minimized.