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1361330-49-5

trans-4-[1-[[2-(5-fluoro-1-methyl-3-indolyl)-7-fluoro-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • trans-4-[1-[[2-(5-fluoro-1-methyl-3-indolyl)-7-fluoro-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid

    Cas No: 1361330-49-5

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  • 1361330-49-5 Structure

  • Basic information

    1. Product Name: trans-4-[1-[[2-(5-fluoro-1-methyl-3-indolyl)-7-fluoro-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid
    2. Synonyms: trans-4-[1-[[2-(5-fluoro-1-methyl-3-indolyl)-7-fluoro-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid
    3. CAS NO:1361330-49-5
    4. Molecular Formula:
    5. Molecular Weight: 569.581
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1361330-49-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: trans-4-[1-[[2-(5-fluoro-1-methyl-3-indolyl)-7-fluoro-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: trans-4-[1-[[2-(5-fluoro-1-methyl-3-indolyl)-7-fluoro-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid(1361330-49-5)
    11. EPA Substance Registry System: trans-4-[1-[[2-(5-fluoro-1-methyl-3-indolyl)-7-fluoro-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid(1361330-49-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1361330-49-5(Hazardous Substances Data)

1361330-49-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1361330-49-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,1,3,3 and 0 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1361330-49:
(9*1)+(8*3)+(7*6)+(6*1)+(5*3)+(4*3)+(3*0)+(2*4)+(1*9)=125
125 % 10 = 5
So 1361330-49-5 is a valid CAS Registry Number.

1361330-49-5Downstream Products

1361330-49-5Relevant articles and documents

Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6- benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist

Setoguchi, Masaki,Iimura, Shin,Sugimoto, Yuuichi,Yoneda, Yoshiyuki,Chiba, Jun,Watanabe, Toshiyuki,Muro, Fumihito,Iigo, Yutaka,Takayama, Gensuke,Yokoyama, Mika,Taira, Tomoe,Aonuma, Misato,Takashi, Tohru,Nakayama, Atsushi,MacHinaga, Nobuo

, p. 1201 - 1212 (2012/03/26)

For the purpose of obtaining orally potent VLA-4 inhibitors, we have carried out structural modification of the (N′-phenylureido)phenyl group in compound 1, where the group was found to be attributed to poor pharmacokinetic profile in our previous research. Through modification, we have identified several compounds with both potent in vitro activity and improved oral exposure. In particular, compound 7e with 7-fluoro-2-(1-methyl-1H-indol-3- yl)-1,3-benzoxazolyl group as a novel replacement of the (N′-phenylureido) phenyl group significantly inhibited eosinophil infiltration into bronchoalveolar lavage fluid at 15 mg/kg in an Ascaris-antigen-induced murine bronchial inflammatory model, and its efficacy was comparable to that of the anti-mouse α4 antibody (R1-2).

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