441715-30-6

Basic information

• Product Name: 5-FLUORO-1-METHYL-1H-INDOLE-3-CARBALDEHYDE
• Synonyms: 5-FLUORO-1-METHYL-1H-INDOLE-3-CARBALDEHYDE;5-FLUORO-1-METHYLINDOLE-3-CARBOXALDEHYDE;AKOS JY2083309;Albb-005049;5-fluoro-1-methyl-1H-indole-3-carbaldehyde(SALTDATA: FREE);1H-indole-3-carboxaldehyde, 5-fluoro-1-methyl-;5-fluoro-1-methyl-1H-indole-3-carboxaldehyde
• CAS NO: 441715-30-6
• Molecular Formula: C₁₀H₈FNO
• Molecular Weight: 177.18
• Product Categories: Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Heterocyclic Fluorinated Building Blocks;Indoles;Other Fluorinated Heterocycles
• Mol File: 441715-30-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 322.3°C at 760 mmHg
• Flash Point: 148.7°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0.000281mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 5-FLUORO-1-METHYL-1H-INDOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-1-METHYL-1H-INDOLE-3-CARBALDEHYDE(441715-30-6)
• EPA Substance Registry System: 5-FLUORO-1-METHYL-1H-INDOLE-3-CARBALDEHYDE(441715-30-6)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 441715-30-6(Hazardous Substances Data)

Usage

General Description

5-FLUORO-1-METHYL-1H-INDOLE-3-CARBALDEHYDE is a chemical compound with the molecular formula C10H8FNO. It is a fluorescent yellow solid that is commonly used in organic synthesis and medicinal chemistry. 5-FLUORO-1-METHYL-1H-INDOLE-3-CARBALDEHYDE has potential applications in the development of pharmaceuticals, agrochemicals, and dyes. It is a derivative of the indole class of compounds, which are known for their diverse range of biological activities. 5-FLUORO-1-METHYL-1H-INDOLE-3-CARBALDEHYDE may have potential as a building block for the synthesis of new drugs and research chemicals due to its unique structure and properties.

InChI:InChI=1/C10H8FNO/c1-12-5-7(6-13)9-4-8(11)2-3-10(9)12/h2-6H,1H3

Upstream product

• 116176-92-2 5-fluoro-1-methyl-1H-indole 
• 298-12-4 Glyoxilic acid 
• 67-68-5 dimethyl sulfoxide 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 68-12-2 N,N-dimethyl-formamide 
• 399-52-0 5-fluoro-1H-indole 
• 2338-71-8 5-fluoro-1H-indole-3-carbaldehyde 
• 74-88-4 methyl iodide 

Downstream Products

• 441715-98-6 C₃₁H₃₃F₂N₃O₅ 
• 1361330-49-5 trans-4-[1-[[2-(5-fluoro-1-methyl-3-indolyl)-7-fluoro-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid 
• 441716-01-4 methyl trans-4-[1-[[2-(5-fluoro-1-methyl-3-indolyl)-7-fluoro-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate 
• 441712-72-7 trans-4-[1-[[2-(5-fluoro-1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid 
• 1609064-35-8 N-[2-(5-fluoro-1-methyl-1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide 
• 910381-19-0 2-(5-fluoro-1-methyl-1H-indol-3-yl)ethan-1-amine 

Relevant articles and documents

Pd(II)-Catalyzed asymmetric oxidative annulation of N-alkoxyheteroaryl amides and 1,3-dienes

The first Pd(II)-catalyzed asymmetric oxidative annulation of N-alkoxyaryl amides and 1,3-dienes is reported, which features particular applicability for quick assembly of different types of chiral heterocycles with high yields and enantioselectivities. A novel chiral pyridine-oxazoline bearing a methoxyl group at the C-5 position and a gem-dimethyl group on the oxazoline moiety was found to be crucial for conversion.

Indole-substituted hydrazide derivatives and uses thereof

The invention discloses indole-substituted hydrazide derivatives and a use thereof, concretely relates to novel indole-substituted hydrazide derivatives and a medicinal composition including the abovecompounds, a use of the derivatives and the medicinal composition in the protection of nerve cells, and also relates to a method for preparing the compounds and the medicinal composition, and a use of the compounds and the medicinal composition in the preparation of drugs for treating diseases associated with glutamate excitotoxicity and oxidative stress damage or free radicals, or neurodegenerative diseases, especially the Alzheimer disease.

Visible Light-Driven C-3 Functionalization of Indoles over Conjugated Microporous Polymers

Metal-free and heterogeneous organic photocatalysts provide an environmentally friendly alternative to traditional metal-based catalysts. This paper reports a series of carbazole-based conjugated microporous polymers (CMPs) with tunable redox potentials and explores their photocatalytic performance with regard to C-3 formylation and thiocyanation of indoles. Conjugated polymers were synthesized through FeCl3 mediated Friedel-Crafts reactions, and their redox potentials were well regulated by simply altering the nature of the core (i.e., 1,4-dibenzyl, 1,3,5-tribenzyl, or 1,3,5-triazin-2,4,6-triyl). The resulting CMPs exhibited high surface areas, visible light absorptions, and tunable semiconductor-range band gaps. With the highest oxidative capability, CMP-CSU6 derived from 1,3,5-tri(9H-carbazol-9-yl)benzene showed the highest efficiency for C-3 formylation and thiocyanation of indoles at room temperature. Notably, the as-made catalysts can be easily recovered with good retention of photocatalytic activity and reused at least five times, suggesting good recyclability. These results are significant for constructing high-performance porous polymer catalysts with tunable photoredox potentials targeting an efficient material design for catalysis.