1361345-74-5

Upstream product

• 938-24-9 indantrione 
• 100-63-0 phenylhydrazine 
• 762-42-5 dimethyl acetylenedicarboxylate 

Relevant academic research and scientific papers

One-pot synthesis of 4-(2,3-dihydro-2-hydroxy-1,3-dioxo-1H-inden-2-yl)- substituted 1-aryl-1H-pyrazole-3-carboxylates via a tandem three-component reaction

The hitherto unreported, highly functionalized 1H-pyrazole-3-carboxylates 3 have been synthesized in good yields via a one-pot three-component domino reaction of phenylhydrazines, dialkyl acetylenedicarboxylates, and ninhydrin under mild conditions for the first time. No co-catalyst or activator is required for this multicomponent reaction, and the reaction is, from an experimental point of view, simple to perform (Scheme 1). The structures of compounds 3 were corroborated spectroscopically (IR, 1H- and 13C-NMR, and EI-MS) and by elemental analyses. A plausible mechanism for this type of cyclization/addition reaction is proposed (Scheme 2). Copyright