136136-41-9Relevant academic research and scientific papers
Imine-Palladacycles as Phosphine-Free Precatalysts for Low-Temperature Suzuki-Miyaura Synthesis of Nucleoside Analogues in Aqueous Media
Serrano, José Luis,García, Luis,Pérez, José,Lozano, Pedro,Correia, Jevy,Kori, Santosh,Kapdi, Anant R.,Sanghvi, Yogesh S.
, p. 4479 - 4490 (2020)
The synthesis and characterization of new water-soluble dinuclear palladacycles of the general formula [{Pd(R-C^N-SO3Na)(μ-AcO)}2] (R = H (1), OMe (2), Cl (3)) incorporating an ortho-metalated sodium 4-(N-benzylideneamino)benzenesulfonate moiety is reported. These complexes have been revealed to be excellent phosphine-free catalysts for the synthesis of functionalized nucleoside analogues involving a low-temperature Suzuki-Miyaura coupling of 5-iodo-2′-deoxyuridine with different arylboronic acids in neat water. The potential of 1-3 as synthetic precursors was also tested, and bridging acetates were cleaved by reaction with neutral PPh3, yielding the corresponding mononuclear derivatives [Pd(R-C^N-SO3Na)(AcO)(PPh3)] (R = H (4), MeO (5), Cl (6)). Analytical and spectroscopic techniques confirmed the proposed formulas and reactivities reported for complexes 1-6. Structural characterization by X-ray diffraction of single crystals grown from samples of 4 and 6 produced the unexpected but valuable crystallization-mediated compounds 4cm and 6cm that also supported the results presented here.
PALLADIUM CATALYZED COUPLING REACTION FOR THE SYNTHESIS OF C-5 ARYL AND HETEROARYL SUBSTITUTED 2'-DEOXYCYTIDINE
Hassan, Mohamed E.
, p. 1295 - 1299 (2007/10/02)
Cytosine nucleosides substituted at C-5 with differently substituted aryls and heteroaryls have been prepared via a palladium catalyzed reaction utilizing 5-chloromercuri or acetoxymercuri nucleosides and haloarenes or heteroarenes.
