1361388-57-9Relevant academic research and scientific papers
1,4-DIARYL-2-AZETIDINONES WITH ANTI-TUMORAL ACTIVITY
-
Page/Page column 27, (2013/03/26)
Disclosed are compounds of formula (I): wherein one of A and B is the group:(II) wherein R1 is selected from H and OCH3, and the other is the group:(III) wherein R2 is selected from H, OH, NO2, NH2; R
Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: Activation of adenosine monophosphate activated protein kinase and induction of apoptosis
Tripodi, Farida,Pagliarin, Roberto,Fumagalli, Gabriele,Bigi, Alessandra,Fusi, Paola,Orsini, Fulvia,Frattini, Milo,Coccetti, Paola
experimental part, p. 2112 - 2124 (2012/05/21)
A series of novel 1,4-diaryl-2-azetidinones were synthesized and evaluated for antiproliferative activity, cell cycle effects, and apoptosis induction. Strong cytotoxicity was observed with the best compounds (±)-trans-20, (±)-trans-21, and enantiomers (+
