1361409-74-6

Basic information

• Product Name: C₂₀H₂₃N₅O₃
• Synonyms: C₂₀H₂₃N₅O₃
• CAS NO: 1361409-74-6
• Molecular Weight: 381.434
• Mol File: 1361409-74-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₃N₅O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₃N₅O₃(1361409-74-6)
• EPA Substance Registry System: C₂₀H₂₃N₅O₃(1361409-74-6)

Safety Data

• Hazardous Substances Data: 1361409-74-6(Hazardous Substances Data)

Upstream product

• 14860-64-1 4-azidoaniline 
• 30925-08-7 (S)-1-(N-tert-butoxycarbonyl-N-methylamino)-1-phenylacetic acid 

Downstream Products

• 1361409-75-7 (S)-3-(1-(4-(2-(2-(1H-indol-3-yl)-N-methylacetamido)-2-phenylacet-amido)phenyl)-1H-1,2,3-triazol-4-yl)propyl-4-methylbenzenesulfonate 
• 1361409-72-4 (S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-(4-(3-fluoropropyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-phenylacetamide 
• 1361409-77-9 (S)-tert-butyl 2-(4-azidophenylamino)-2-oxo-1-phenylethyl(methyl)-carbamate 
• 1145835-70-6 (S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-azidophenyl)-2-phenylacetamide 

Relevant articles and documents

Fluorinated DF508-CFTR correctors and potentiators for PET imaging

19F-modified bithiazole correctors and phenylglycine potentiators of the DF508-CFTR chloride channel were synthesized and their function assayed in cells expressing human DF508-CFTR and a halide-sensitive fluorescent protein. Fluorine was incorporated into each scaffold using prosthetic groups for future biodistribution imaging studies using positron emission tomography (PET). The DF508-CFTR corrector and potentiator potencies of the fluorinated analogs were comparable to or better than those of the original compounds.