1361409-75-7

Upstream product

• 1361409-74-6 C₂₀H₂₃N₅O₃ 
• 1361409-77-9 (S)-tert-butyl 2-(4-azidophenylamino)-2-oxo-1-phenylethyl(methyl)-carbamate 
• 1145835-70-6 (S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-azidophenyl)-2-phenylacetamide 
• 77758-50-0 4-pentynyl-1-tosylate 
• 5390-04-5 pent-1-yn-5-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 14860-64-1 4-azidoaniline 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 1361409-72-4 (S)-2-(2-(1H-indol-3-yl)-N-methylacetamido)-N-(4-(4-(3-fluoropropyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-phenylacetamide 

Relevant academic research and scientific papers

Fluorinated DF508-CFTR correctors and potentiators for PET imaging

19F-modified bithiazole correctors and phenylglycine potentiators of the DF508-CFTR chloride channel were synthesized and their function assayed in cells expressing human DF508-CFTR and a halide-sensitive fluorescent protein. Fluorine was incorporated into each scaffold using prosthetic groups for future biodistribution imaging studies using positron emission tomography (PET). The DF508-CFTR corrector and potentiator potencies of the fluorinated analogs were comparable to or better than those of the original compounds.