1361411-70-2Relevant articles and documents
Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations
Valverde, Ibai E.,Lecaille, Fabien,Lalmanach, Gilles,Aucagne, Vincent,Delmas, Agnes F.
, p. 718 - 722 (2012)
"Click" protein: CuI-catalyzed cycloaddition of azides and terminal alkynes has been applied to the successive ligations of three unprotected peptide fragments. Peptidomimetic triazole ligation (PTL, see scheme) as a new method for the chemical production of bioactive proteins is applied for the synthesis of a triazole-containing analogue of the 97 amino acid protein cystatin A. Copyright