1361414-22-3

Upstream product

• 1235544-51-0 2-(4-((ethoxycarbonothioyl)thio)phenyl)acetic acid 
• 39161-84-7 4-mercaptophenylacetic acid 
• 1197-55-3 4-aminophenylacetic acid 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 91361-92-1 (4-mercapto-phenyl)-acetic acid methyl ester 

Downstream Products

• 1361413-38-8 N-[5-[(2-chlorophenyl)carbonyl]-4-(3-cyanophenyl)-1,3-thiazol-2-yl]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide 
• 1363178-92-0 N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yI]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide 
• 1153070-21-3 2-(4-((2,2,2-trifluoroethyl)sulfonyl)phenyl)acetic acid 
• 1361414-24-5 methyl 2-(4-((2,2,2-trifluoroethyl)sulfonyl)phenyl)acetate 

Relevant academic research and scientific papers

FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

NOVEL COMPOUNDS

Novel retinoid-related orphan receptor gamma (ROR?) modulators and their use in the treatment of diseases mediated by ROR? provided by the present invention.

NOVEL COMPOUNDS

Disclosed are retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.