136146-69-5Relevant academic research and scientific papers
Leveraging the micellar effect: Gold-catalyzed dehydrative cyclizations in water at room temperature
Minkler, Stefan R. K.,Isley, Nicholas A.,Lippincott, Daniel J.,Krause, Norbert,Lipshutz, Bruce H.
, p. 724 - 726 (2014/03/21)
The first examples of gold-catalyzed cyclizations of diols and triols to the corresponding hetero- or spirocycles in an aqueous medium are presented. These reactions take place within nanomicelles, where the hydrophobic effect is operating, thereby driving the dehydrations, notwithstanding the surrounding water. By the addition of simple salts such as sodium chloride, reaction times and catalyst loadings can be significantly decreased.
An extremely facile synthesis of furans, pyrroles, and thiophenes by the dehydrative cyclization of propargyl alcohols
Aponick, Aaron,Li, Chuan-Ying,Malinge, Jeremy,Marques, Emerson Finco
supporting information; experimental part, p. 4624 - 4627 (2009/12/09)
Furans, pyrroles, and thiophenes are efficiently prepared by gold-catalyzed dehydrative cyclizations of readily available, heteroatom-substituted propargyllc alcohols. The reactions are rapid, high-yielding, and procedurally simple, giving essentially pure aromatic heterocycles In minutes under open-flask conditions with catalyst loadings as low as 0.05 mol %.
SYNTHESIS OF 1-ALKYL-2-ARYLPYRROLES FROM ARYL(3-BROMO-2-METHOXYPROPYL)KETONES
Sorokin, V. L.,Azzuz, A. A.,Kulinovich, O. G.
, p. 271 - 272 (2007/10/02)
Aryl(3-bromo-2-methoxypropyl)ketones have been obtained by bromination of allylarylketones using N-bromosuccinimide.When treated with primary amines, good yields of 1-alkyl-2-arylpyrroles were obtained via 1,3-dehydrobromination and subsequent opening of
