1361493-70-0

Basic information

• Product Name: N-tert-butyl-2-(p-chlorophenyl)-5-chloroquinazoline-4-amine
• Synonyms: N-tert-butyl-2-(p-chlorophenyl)-5-chloroquinazoline-4-amine
• CAS NO: 1361493-70-0
• Molecular Weight: 346.259
• Mol File: 1361493-70-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-tert-butyl-2-(p-chlorophenyl)-5-chloroquinazoline-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butyl-2-(p-chlorophenyl)-5-chloroquinazoline-4-amine(1361493-70-0)
• EPA Substance Registry System: N-tert-butyl-2-(p-chlorophenyl)-5-chloroquinazoline-4-amine(1361493-70-0)

Safety Data

• Hazardous Substances Data: 1361493-70-0(Hazardous Substances Data)

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 873-38-1 4-chloro-2-bromoaniline 
• 119072-55-8 tert-butylisonitrile 
• 1361493-59-5 N'-(2-bromo-4-chlorophenyl)-4-chlorobenzimidamide 

Relevant articles and documents

Synthesis of 4-aminoquinazolines by palladium-catalyzed intramolecular imidoylation of N-(2-bromoaryl)amidines

Compared with the widespread use of carbonylative Pd-catalyzed cross-coupling reactions, similar reactions involving isocyanide insertion are almost virgin territory. We investigated the intramolecular imidoylative cross-coupling of N-(2-bromoaryl)amidines, leading to 4-aminoquinazolines. After thorough optimization of the reaction with respect to palladium source and loading, ligand, base, temperature, and solvent, a small library of 4-aminoquinazolines was prepared to determine the scope of this method. Various substituents are tolerated on the amidine and the isocyanide, providing efficient access to a broad range of diversely substituted 4-aminoquinazolines of significant pharmaceutical interest.