136160-29-7

Upstream product

• 462-95-3 formaldehyde diethyl acetal 
• 171048-63-8 6-benzyl-5-ethylpyrimidine-2,4(1H,3H)-dione 
• 3188-13-4 ethyl chloromethyl ether 
• 199851-89-3 6-benzyl-5-ethyl-2-thiouracil 
• 103-80-0 phenylacetyl chloride 
• 718-08-1 ethyl 3-oxo-4-phenylbutyrate 
• 171855-61-1 ethyl 2-ethyl-3-oxo-4-phenylbutanoate 
• 4212-49-1 5-ethyluracil 
• 1026724-09-3 1-Ethoxymethyl-5-ethyl-6-(hydroxy-phenyl-methyl)-1H-pyrimidine-2,4-dione 
• 136160-48-0 1-(ethoxymethyl)-5-ethyluracil 
• 100-52-7 benzaldehyde 
• 165960-77-0 6-(acetoxyphenylmethyl)-1-(ethoxymethyl)-5-ethyluracil 

Downstream Products

• 1026964-03-3 6-Benzyl-5-ethyl-1-(2-methoxy-ethyl)-3-(2-oxo-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione 
• 1026908-96-2 6-Benzyl-1-butyl-5-ethyl-3-(2-oxo-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione 
• 165960-83-8 6-benzyl-5-ethyl-3-phenacyluracil 
• 1026639-67-7 6-Benzyl-1-ethoxymethyl-5-ethyl-3-(2-oxo-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Easy synthesis of 5,6-disubstituted acyclouridine derivatives

Ethyl 2-ethyl-3-oxo-4-phenylbutyrate is synthesized in a high yield from the corresponding benzyl cyanide and ethyl 2-bromobutyrate or by reaction of the potassium salt of ethyl 2-ethylmalonate with phenylacetyl chloride. Condensation of the 3-oxo ester w

New efficient and flexible synthetic route to Emivirine and its analogs

A revised synthetic route to Emivirine (MKC-442) via properly substituted β-keto ester converted from Meldrum's Acid was developed. This method could be applied to the synthesis of a variety of MKC-442 analogues and open the way for their systematic biological evaluation.

Synthesis and antiviral activity of 6-benzyl analogs of 1-[(2- hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents

Several 6-benzyl analogs of 1-[(2-hydroxyethoxy)methyl]-6- (phenylthio)thymine (1; HEPT) were synthesized and evaluated for their anti- HIV-1 activity. LDA (lithium diisopropylamide) lithiation of 5-ethyluracil derivatives 7 and 8 and subsequent reaction with an aryl aldehyde gave 6- (arylhydroxymethyl)-5-ethyluracil derivatives 9-12. 6-(Arylhydroxymethyl)-5- isopropyluracil derivatives 15-18 were prepared from the 5-isopropyl-2- thiouracil derivatives 13 and 14 by the above procedure following oxidative hydrolysis of the thione. Preparation of the target 5-alkyl-1-(alkoxymethyl)- 6-benzyluracil derivatives 27-34 was carried out by acetylation of 9-14 followed by Pd-catalyzed hydrogenolysis. The 1-butyl- (37 and 39) and 1-(2- methoxyethyl)- (38 and 40) 5-alkyl-6-benzyluracils were synthesized by 1- alkylation of the 3-phenacyl derivatives 35 and 36 with alkyl halides followed by deprotection of the 3-phenacyl group. Compounds synthesized in this study inhibited HIV-1 replication in MT-4 cells in the submicromolar to nanomolar concentration range. From this series of compounds, 6-benzyl-1- (ethoxymethyl)-5-isopropyluracil (33) was selected for clinical evaluation.

Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof

The disclosure concerns pyrimidine derivatives represented by the following general formulas [I] and [I'] and having antiviral activity, particularly antiretroviral activity such as anti-HIV activity: STR1 and pharmaceutical compositions having antiviral