136194-44-0

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 1242188-85-7 N,N'-[4,4'-sulfonylbis(benzoyl)]-bis{4,4'-(p-fluorobenzyl)-1,2-dihydroisoquinaldonitrile} 
• 1242188-84-6 N,N'-(4,4'-oxybisbenzoyl)-bis{4,4'-(p-fluorobenzyl)-1,2-dihydroisoquinaldonitrile} 
• 1242188-89-1 N,N'-[sulfonylbis(p-phenyleneoxy)]-bis(4,4'-(p-fluorobenzyl)-1,2-dihydroisoquinaldonitrile) 
• 1242188-91-5 p-bis{1-[4-(p-fluorobenzoyl)isoquinolyl]carbonyl}benzene 
• 1242188-90-4 α,α'-dihydroxy-α,α'-bis{1-[4-(p-fluorobenzyl)isoquinolyl]}-p-xylene 
• 136214-25-0 2-benzoyl-4-(p-fluorobenzyl)-1,2-dihydroisoquinaldonitrile 

Relevant academic research and scientific papers

Microwave-Assisted Palladium-Catalyzed Reductive Cyclization/Ring-Opening/Aromatization Cascade of Oxazolidines to Isoquinolines

An efficient palladium-catalyzed reaction of N-propargyl oxazolidines for the construction of 4-substituted isoquinolines under microwave irradiation is developed. This transformation proceeds through a sequential palladium-catalyzed reductive cyclization/ring-opening/aromatization cascade via C-O and C-N bond cleavages of the oxazolidine ring. The practical value of this method has also been explored by conducting a millimole-scale reaction, as well as by transforming the isoquinoline into a key intermediate for the synthesis of a lamellarin analogue.