1361944-03-7Relevant academic research and scientific papers
Iron(III)/NaBH4-mediated additions to unactivated alkenes: Synthesis of novel 20′-vinblastine analogues
Leggans, Erick K.,Barker, Timothy J.,Duncan, Katharine K.,Boger, Dale L.
, p. 1428 - 1431 (2012)
An Fe(III)/NaBH4-mediated reaction for the functionalization of unactivated alkenes is described defining the alkene substrate scope, establishing the exclusive Markovnikov addition, exploring a range of free radical traps, examining the Fe(III) salt and initiating hydride source, introducing H2O-cosolvent mixtures, and exploring catalytic variants. Its use led to the preparation of a novel, potent, and previously inaccessible C20′-vinblastine analogue.
