1361982-34-4Relevant academic research and scientific papers
Pd-catalyzed modifiable silanol-directed aromatic C-H oxygenation
Huang, Chunhui,Ghavtadze, Nugzar,Godoi, Benhur,Gevorgyan, Vladimir
supporting information; experimental part, p. 9789 - 9792 (2012/08/29)
Directing group: A Pd-catalyzed aromatic C-H oxygenation has been developed, featuring a modifiable silanol-directing group. The resulting oxasilacycles can be efficiently modified into a variety of valuable building blocks (see scheme). Copyright
Silanol as a removable directing group for the pdII-catalyzed direct olefination of arenes
Wang, Cong,Ge, Haibo
supporting information; experimental part, p. 14371 - 14374 (2012/01/19)
Need some direction? Silanol was developed as a directing group for the PdII-catalyzed oxidative Heck-type reaction of arenes. A one-pot C-H activation/desilylation process of benzyldiisopropylsilanol was also demonstrated, providing a powerful approach for the synthesis of ortho-alkenyl-substituted alkylarenes (see scheme). Considering the easily attachable and readily removable properties of the silanol group, this reaction will find broad synthetic applications.
