13620-31-0

Basic information

• Product Name: Acetonitrile, (phenylmethoxy)-
• CAS NO: 13620-31-0
• Molecular Formula: C9H9NO
• Molecular Weight: 147.177
• Mol File: 13620-31-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Acetonitrile, (phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetonitrile, (phenylmethoxy)-(13620-31-0)
• EPA Substance Registry System: Acetonitrile, (phenylmethoxy)-(13620-31-0)

Safety Data

• Hazardous Substances Data: 13620-31-0(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 143-33-9 sodium cyanide 
• 100-44-7 benzyl chloride 
• 151-50-8 potassium cyanide 
• 100-51-6 benzyl alcohol 
• 32122-09-1 ethyl benzyloxyacetate 
• 60656-87-3 benzyloxyacetoaldehyde 
• 590-17-0 cyanomethyl bromide 
• 5774-77-6 2-(benzyloxy)acetamide 

Downstream Products

• 32122-09-1 ethyl benzyloxyacetate 
• 22539-93-1 3-benzyloxypropanone 
• 437985-55-2 1-(benzyloxymethyl)-2-ethylcyclopropylamine 
• 437985-55-2 1-(benzyloxymethyl)-2-ethylcyclopropylamine 
• 929907-27-7 1-benzyloxymethyl-2-phenylcyclopropylamine 
• 291771-24-9 3-benzyloxymethyl-5-dimethylaminomethyl-1,2,4-oxadiazole 
• 291771-26-1 3-benzyloxymethyl-5-methylcyclohexylaminomethyl-1,2,4-oxadiazole 
• 1428548-40-6 ethyl 2-((benzyloxy)methyl)-4-hydroxypyrimidine-5-carboxylate 
• 1428548-41-7 2-((benzyloxy)methyl)-4-hydroxypyrimidine-5-carboxylic acid 
• 1428548-42-8 N-benzhydryl-2-((benzyloxy)methyl)-4-hydroxypyrimidine-5-carboxamide 
• 1428548-47-3 2-[(benzyloxy)methyl]-N-[bis(4-methoxyphenyl)methyl]-4-hydroxypyrimidine-5-carboxamide 
• 1428548-52-0 2-[(benzyloxy)methyl]-N-[bis(4-fluorophenyl)methyl]-4-hydroxypyrimidine-5-carboxamide 
• 1428548-56-4 2-((benzyloxy)methyl)-4-hydroxy-N-(naphthalen-1-ylmethyl)pyrimidine-5-carboxamide 
• 1428548-60-0 2-((benzyloxy)methyl)-4-hydroxy-N-(naphthalen-2-ylmethyl)pyrimidine-5-carboxamide 

Relevant articles and documents

AMINOPYRIMIDINE COMPOUND USED FOR INHIBITING ACTIVITY OF PROTEIN KINASE

The present invention relates to an aminopyrimidine compound having an inhibitory effect on the activity of protein kinase as well as the preparation and use thereof. Specifically, disclosed by the present invention is an aminopyrimidine compound represented by formula (I), or a pharmaceutically acceptable salt, stereoisomer, solvate or hydrate thereof, as well as a pharmaceutical composition comprising said compound and a use method therefor. The method comprises a method for treating cell proliferative diseases and conditions such as cancer and immune diseases.

Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid

Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to L-citrulline and the second messenger nitric oxide. Three mechanistic pathways are proposed for the inactivation of neuronal NOS (nNOS) by (S)-2-amino-5-(2-(methylthio)acetimidamido)pentanoic acid (1): sulfide oxidation, oxidative dethiolation, and oxidative demethylation. Four possible intermediates were synthesized. All compounds were assayed with nNOS, their IC50, KI, and kinact values were obtained, and their crystal structures were determined. The identification and characterization of the products formed during inactivation provide evidence for the details of the inactivation mechanism. On the basis of these studies, the most probable mechanism for the inactivation of nNOS involves oxidative demethylation with the resulting thiol coordinating to the cofactor heme iron. Although nNOS is a heme-containing enzyme, this is the first example of a NOS that catalyzes an S-demethylation reaction; the novel mechanism of inactivation described here could be applied to the design of inactivators of other heme-dependent enzymes.

SUBSTITUTED PYRIMIDINES

The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.