13620-59-2

Upstream product

• 75-52-5 nitromethane 
• 20432-02-4 1-(4-nitro-phenyl)-3-phenyl-propenone 
• 20432-02-4 (E)-4'-nitrochalcone 
• 5153-67-3 nitrostyrene 
• 100-19-6 (4-nitrophenyl)ethanone 
• 102-96-5 (2-nitroethenyl)benzene 
• 38502-65-7 1-(4-nitrophenyl)-3-(4-methoxyphenyl)propane-1,3-dione 

Relevant academic research and scientific papers

Sequential Michael addition/retro-Claisen condensation of 1,3-diarylpropan-1,3-diones with nitrostyrenes: one-step synthesis of 4-nitro-1,3-diarylbutan-1-ones

Abstract : The sequential Michael addition/retro-Claisen condensation of 1,3-diarylpropan-1,3-diones with nitrostyrenes is described. 4-Nitro-1,3-diarylbutan-1-ones were efficiently synthesized in good to high yield under mild, transition-metal-free condition. This one-step method involving sequential carbon-carbon bond formation and cleavage provides a good alternative to the synthesis of various γ-nitro ketones. Graphical abstract: The sequential Michael addition/retro-Claisen condensation of 1,3-diarylpropan-1,3-diones with nitrostyrenes is described. 4-Nitro-1,3-diarylbutan-1-ones were efficiently synthesized in good to high yield under mild and transition-metal-free condition. [Figure not available: see fulltext.].

Enantioselective addition of aryl ketones and acetone to nitroalkenes organocatalyzed by carbamate-monoprotected cyclohexa-1,2-diamines

Enantiomerically pure carbamate-monoprotected trans-cyclohexane-1,2-diamines are used as chiral organocatalysts for the addition of aryl ketones and acetone to nitroalkenes to give enantioenriched β-substituted γ-nitroketones. The reaction was performed i

New synthesis of 1,3-diaryl-4-nitro-1-butanones by microwave-promoted Michael addition of nitromethane to chalcones without solvent

The Michael addition of nitromethane to chalcones promoted by microwave irradiation without solvent afforded 1,3-diaryl-4-nitro-1-butanones in good yield. The products were characterised by IR, 1H NMR and elemental analysis.

Michael Additions Catalyzed by Metal(II) Complexes

Michael-addition reactions have been found to proceed in the presence of the Ni(OAc)2 or Co(OAc)2-2,2'-bypiridine complex in DMF under neutral conditions at room temperature without any by-product.The reactions of chalcone and its derivatives with nitromethane generally gave good results.The effects of metal(II) ions, ligands, counter ions, and solvents on the catalysis were examined, and the features of the metal-complex-catalyzed Michael reactions were studied, with some considerations also being given to the catalysis mechanism.

MICHAEL ADDITIONS CATALYZED BY NICKEL(II) OR COBALT(II)ACETATE-2,2'-BIPYRIDINE COMPLEXES

In the presence of nickel(II) or cobalt(II)acetate-2,2'-bipyridine complexes, α,β-unsaturated ketones, methyl acrylate, and acrylonitrile were found to react with nitromethane, malononitrile, and aniline at room temperature under neutral condition to afford addition products in good yields.