1362020-34-5

Upstream product

• 1362020-68-5 C₁₁H₁₁N₃O₃ 
• 114878-60-3 1-(2-chloro-4-nitro-phenyl)piperazine 
• 1362020-54-9 C₁₃H₁₅N₃O₃ 
• 20442-97-1 2-methoxylphenyl azide 
• 90-04-0 2-methoxy-phenylamine 

Relevant academic research and scientific papers

Novel compound or pharmaceutically acceptable salt thereof and pharmaceutical composition for prevention or treatment of disease caused by influenza virus infection containing the same as an active ingredient

The present invention relates to a novel compound or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active component for preventing or treating diseases related with influenza virus infection. The novel compound represented by chemical formula 1 has remarkable antivirus activity against influenza virus without cytotoxicity to human cells and thus has little side effects to human bodies. Therefore, the pharmaceutical composition having the same as an active component can be usefully used for preventing or treating diseases which occur through influenza virus infection such as flu, cold, sore throat, bronchitis, pneumonia, avian influenza, swine flu, goat flu, etc.COPYRIGHT KIPO 2016

Novel compound or pharmaceutically acceptable salt thereof and pharmaceutical composition for prevention or treatment of disease caused by influenza virus infection containing the same as an active ingredient

The present invention relates to a novel compound or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for preventing or treating diseases caused by influenza virus infection, comprising the same as an active ingredient. The nov

Novel compound or pharmaceutically acceptable salt thereof and pharmaceutical composition for prevention or treatment of disease caused by influenza virus infection containing the same as an active ingredient

The present invention relates to a novel compound or pharmaceutically acceptable salt thereof, and to a pharmaceutical composition containing the same as an active ingredient for treating and preventing disease caused by influenza virus infection. The novel compound represented by chemical formula 1 according to the present invention not only has extremely excellent antivirus activity, but also has less side effects for a human body by not having cytotoxicity for a human cell. Therefore, a pharmaceutical composition containing the same as an active ingredient can be used in preventing or treating such as flu, colds, sore throats, bronchitis, pneumonia, bird flu, swine flu, and goat flu caused by influenza virus infection.COPYRIGHT KIPO 2015

METHANETHIONE COMPOUNDS HAVING ANTIVIRAL ACTIVITY

A compound of formula (I), The compound is useful as an antiviral agent, in particular for the treatment of influenza. A method for preparing the compound of formula (I) and a composition comprising the compound of formula (I).

Design, synthesis, and in vitro biological evaluation of 1 H -1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein

The influenza virus nucleoprotein (NP) is an emerging target for anti-influenza drug development. Nucleozin (1) and its closely related derivatives had been identified as NP inhibitors displaying anti-influenza activity. Utilizing 1 as a lead molecule, we successfully designed and synthesized a series of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents. One of the most potent compounds, 3b, inhibited the replication of various H3N2 and H1N1 influenza A virus strains with IC 50 values ranging from 0.5 to 4.6 μM. Compound 3b also strongly inhibited the replication of H5N1 (RG14), amantidine-resistant A/WSN/33 (H1N1), and oseltamivir-resistant A/WSN/1933 (H1N1, 274Y) virus strains with IC 50 values in sub-μM ranges. Further computational studies and mechanism investigation suggested that 3b might directly target influenza virus A nucleoprotein to inhibit its nuclear accumulation.