136206-75-2

Upstream product

• 41324-66-7 H-Pro-OBzl 
• 136206-73-0 Boc-L-Phe-L-Pro-Gly-L-Pro-L-Phe-L-Pro-Gly-L-Pro-OBzl 
• 70462-58-7 benzyl (tert-butoxycarbonyl)-L-phenylalanyl-L-prolinate 
• 23420-32-8 N-tert-butoxycarbonyl-L-phenylalanyl-L-proline 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 136206-74-1 Boc-L-Phe-L-Pro-Gly-L-Pro-L-Phe-L-Pro-Gly-L-Pro 
• 136236-56-1 Boc-L-Phe-L-Pro-Gly-L-Pro-L-Phe-L-Pro-Gly-L-Pro-OSu 
• 136206-70-7 Boc-L-Phe-L-Pro-Gly-L-Pro-OBzl 
• 136206-71-8 Boc-L-Phe-L-Pro-Gly-L-Pro 
• 136206-72-9 L-Phe-L-Pro-Gly-L-Pro-OBzl 
• 64472-24-8 glycyl-L-proline benzyl ester 
• 29776-78-1 (S)-1-(2-tert-butoxycarbonylaminoacetyl)pyrrolidine-2-carboxylic acid benzyl ester 

Downstream Products

• 136314-94-8 cyclo(L-Phe-L-Pro-Gly-L-Pro)2 

Relevant academic research and scientific papers

Conformational studies of cyclo(L-Phe-L-Pro-Gly-L-Pro)2 by 1H- and 13C-nuclear magnetic resonance spectroscopy, and its enantioface-differentiating ability

Analyses of the 1H- and 13C-nuclear magnetic resonance (1H- and 13C-NMR) spectra of the cyclooctapeptide cyclo (L-Phe-L-Pro-Gly-L-Pro)2 (3) in CDCl3 with the aid of the C-H correlated spectroscopy (C-H COSY) two-dimensional NMR spectrum (Fig. 2) suggested that two kinds of C2-symmetric conformation with all trans and cis-trans-trans-trans forms coexist. When 0.5 eq of CsSCN or 1 eq of D- and L-PheOMe · HCl (D/L ratio = 1/2) was added to a solution of the cyclooctapeptide (3) in CDCl3, the 1H- and 13C-NMR spectra (Fig. 3) suggested the presence of only one C2-symmetric conformation (all trans), resulting from the formation of complexes with CsSCN or D- and L-PheOMe · HCl. The 13C-NMR spectra of the complexes of the cyclooctapeptide (3 or 4) with D- and L-PheOMe · HCl displayed separate resonances for each carbon atom of D-PheOMe · HCl and L-PheOMe · HCl. Furthermore, the ability of 3 to distinguish the D from the L enantiomer, is superior to that of 4 (Table II).

Conformational studies of cyclo(L-Phe-L-Pro-Gly-L-Pro)2 by 13C nuclear magnetic resonance

The 13C-NMR spectrum of cyclooctapeptide cyclo(L-PHe-L-Pro-Gly-L-Pro)2 (A) in CDCl3 suggested that its conformation involved the coexistence of two kinds of C2-symmetric conformation with trans-trans-trans-trans