13623-53-5Relevant academic research and scientific papers
Isoform-selective inhibitory profile of 2-imidazoline-substituted benzene sulfonamides against a panel of human carbonic anhydrases
Supuran, Claudiu T.,Kalinin, Stanislav,Tan?, Muhammet,Sarnpitak, Pakornwit,Mujumdar, Prashant,Poulsen, Sally-Ann,Krasavin, Mikhail
, p. 197 - 202 (2016/12/03)
A series of novel benzene sulfonamides (previously evaluated as selective cyclooxygenase-2 inhibitors) has been profiled against human carbonic anhydrases I, II, IV and VII in an attempt to observe the manifestation of the well established “tail” approach
Pd-catalyzed N-arylation of 2-imidazolines provides convenient access to selective cyclooxygenase-2 inhibitors
Krasavin, Mikhail
, p. 235 - 239 (2013/07/26)
The re-emergence, in the recent years, of cyclooxygenase as a biological target in therapeutic areas other than inflammation is likely to require new optimized leads, particularly suited for the requirements of specific drug development programs. We devel
A simple two-step access to diversely substituted imidazo[4,5-b]pyridines and benzimidazoles from readily available 2-imidazolines
Mujumdar, Prashant,Grkovic, Tanja,Krasavin, Mikhail
, p. 3336 - 3340 (2013/07/05)
We discovered a facile rearrangement of N-(hetero)aryl 2-imidazolines into diversely substituted imidazo[4,5-b]pyridines and benzimidazoles, under Bechamp reduction conditions. Combined with the earlier reported protocol for Pd-catalyzed (hetero)arylation of 2-imidazolines, it provides a simple two-step access to a range of compounds based on these medicinally important heterocyclic cores.
