1362317-63-2

Upstream product

• 1362317-62-1 2-azido-N-(2-(tert-butyldimethylsilyloxy)ethyl)ethanamine 
• 168263-86-3 N⁴-benzoylcytosine-1-acetic acid 
• 86864-60-0 2-(tert-butyldimethylsilyloxy)ethyl bromide 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 186046-91-3 methyl (cytosine-1-yl)acetate 

Downstream Products

• 1362317-67-6 2-(N-((1-(2-(2-(N₄-(benzoyl)cytosin-1-yl)-N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)acetamido)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite 
• 1362317-68-7 C₁₇H₁₉N₇O₄ 
• 1362317-64-3 N-(1-(2-((2-azidoethyl)(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)amino)-2-oxoethyl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide 
• 1362317-65-4 C₅₅H₆₄N₁₀O₁₀Si 
• 1362317-66-5 C₄₉H₅₀N₁₀O₁₀ 

Relevant academic research and scientific papers

Efficient synthesis and cell-based silencing activity of siRNAS that contain triazole backbone linkages

An efficient synthesis of siRNAs modified at the backbone with a triazole functionality is reported. Through the use of 4,4×-dimethoxytrityl (DMT) phosphoramidite chemistry, triazole backbone dimmers were site-specifically incorporated throughout various siRNAs targeting both firefly luciferase and glyceraldehyde- 3-phosphate dehydrogenase (GAPDH) gene transcripts as representatives of an exogenous and endogenous gene, respectively. Following the successful silencing of the firefly luciferase reporter gene, triazole-modified siRNAs were also found to be capable of silencing GAPDH in a dose-dependent manner. Backbone modifications approaching the 3×-end on the sense strand were tolerated without compromising siRNA potency. This study highlights the compatibility of triazole-modified siRNAs within the RNAi pathway, and the modification's potential to impart favorable properties to siRNAs designed to target other endogenous genes.