168263-86-3

Upstream product

• 26661-13-2 4-N-benzoylcytosine 
• 98-88-4 benzoyl chloride 
• 186046-91-3 methyl (cytosine-1-yl)acetate 
• 168263-85-2 N₄-Benzoyl-1-tert-butyloxycarbonylmethylcytosine 

Downstream Products

• 857250-43-2 {[[2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid diphenyl ester 
• 172405-22-0 [[(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-acetic acid methyl ester 
• 473268-79-0 2-({allyloxycarbonylmethyl-[(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1160163-44-9 C₄₄H₅₂N₆O₉ 
• 1253933-48-0 C₃₈H₃₈N₄O₇ 
• 1280548-86-8 C₃₇H₃₆N₄O₇ 
• 1280548-93-7 C₄₆H₅₃N₆O₈P 
• 1362317-67-6 2-(N-((1-(2-(2-(N₄-(benzoyl)cytosin-1-yl)-N-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)acetamido)ethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(uracil-1-yl)acetamido)ethyl (2-cyanoethyl)diisopropylphosphoramidite 
• 1362317-68-7 C₁₇H₁₉N₇O₄ 
• 1362317-64-3 N-(1-(2-((2-azidoethyl)(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)amino)-2-oxoethyl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide 
• 1362317-65-4 C₅₅H₆₄N₁₀O₁₀Si 
• 1362317-66-5 C₄₉H₅₀N₁₀O₁₀ 
• 1362317-63-2 C₂₃H₃₃N₇O₄Si 
• 184159-47-5 [([2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-amino)-methyl]-phosphonic acid diphenyl ester 

Relevant academic research and scientific papers

Highly stable triple helix formation by homopyrimidine (l)-acyclic threoninol nucleic acids with single stranded DNA and RNA

Acyclic (l)-threoninol nucleic acid (aTNA) containing thymine, cytosine and adenine nucleobases were synthesized and shown to form surprisingly stable triplexes with complementary single stranded homopurine DNA or RNA targets. The triplex structures consist of two (l)-aTNA strands and one DNA or RNA, and these triplexes are significantly stronger than the corresponding DNA or RNA duplexes as shown in competition experiments. As a unique property the (l)-aTNAs exclusively form triplex structures with DNA and RNA and no duplex structures are observed by gel electrophoresis. The results were compared to the known enantiomer (d)-aTNA, which forms much weaker triplexes depending upon temperature and time. It was demonstrated that (l)-aTNA triplexes are able to stop primer extension on a DNA template, showing the potential of (l)-aTNA for antisense applications. This journal is

Click nucleic acid polymers and methods of use

Disclosed herein are Click Nucleic Acid Polymers (CNA-polymers) that comprise repeating dimer, trimer and tetramer units. The disclosed polymers can be used for antisense applications, for example, in treatment of “trinucleotide repeat disorders, i.e., Hu

Efficient synthesis and cell-based silencing activity of siRNAS that contain triazole backbone linkages

An efficient synthesis of siRNAs modified at the backbone with a triazole functionality is reported. Through the use of 4,4×-dimethoxytrityl (DMT) phosphoramidite chemistry, triazole backbone dimmers were site-specifically incorporated throughout various siRNAs targeting both firefly luciferase and glyceraldehyde- 3-phosphate dehydrogenase (GAPDH) gene transcripts as representatives of an exogenous and endogenous gene, respectively. Following the successful silencing of the firefly luciferase reporter gene, triazole-modified siRNAs were also found to be capable of silencing GAPDH in a dose-dependent manner. Backbone modifications approaching the 3×-end on the sense strand were tolerated without compromising siRNA potency. This study highlights the compatibility of triazole-modified siRNAs within the RNAi pathway, and the modification's potential to impart favorable properties to siRNAs designed to target other endogenous genes.

Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids

There are described N-ethylglycine derivatives of the formula I in which PG is a urethane-type or trityl-type amino protective group which is labile to weak acids, X is NH, O or S, Y is CH2, NH or O, and B' are bases customary in nucleotide chemistry, the exocyclic amino or hydroxyl groups of which being protected by suitable, known protective groups, or are base substitute compounds, and their salts with tert-organic bases, as well as a process for their preparation. The N-ethylglycine derivatives of the formula I are used in the preparation of PNA and PNA/DNA hybrids.

Nucleic acid-binding oligomers possessing N-branching for therapy and diagnostics

The invention relates to nucleic acid-binding oligomers possessing N-branching of the general formula (I), STR1 and their monomers, where the individual radicals have the meaning given in the description, and to their use as medicaments or as aids in diag