136265-59-3Relevant academic research and scientific papers
The design, synthesis, and: In vitro trypanocidal and leishmanicidal activities of 1,3-thiazole and 4-thiazolidinone ester derivatives
Haroon, Muhammad,De Barros Dias, Mabilly Cox Holanda,Santos, Aline Caroline da Silva,Pereira, Valéria Rêgo Alves,Freitas, Luiz Alberto Barros,Balbinot, Rodolfo Bento,Kaplum, Vanessa,Nakamura, Celso Vataru,Alves, Luiz Carlos,Brayner, Fábio André,Leite, Ana Cristina Lima,Akhtar, Tashfeen
, p. 2487 - 2500 (2021/01/29)
Chagas and leishmaniasis are both neglected tropical diseases, whose inefficient therapies have made them remain the cause for millions of deaths worldwide. Given this, we synthesized 27 novel 1,3-thiazoles and 4-thiazolidinones using bioisosteric and est
BROMINATION OF 2-THIAZOLYLHYDRAZONES
Usol'tseva, S. V.,Andronnikova, G. P.,Shevyrin, V. A.
, p. 226 - 230 (2007/10/02)
Bromination of the 4-carbethoxy- and 4-carboxy-2-thiazolylhydrazones of aldehydes and ketones occurs principally at the 5 position of the thiazole ring.In the case of aldehyde hydrazones an excess of bromine leads to substitution of the methine hydrogen atom and to intramolecular cyclization of the intermediate halohydrazone to 1,2,4-triazolothiazole.
SYNTHESIS AND SOME REACTIONS OF 4-CARBOXY-2-THIAZOLYLHYDRAZONES
Bredikhina, Z. A.,Buzykin, B. I.,Kitaev, Yu. P.
, p. 427 - 433 (2007/10/02)
The condensation of thiosemicarbazones with bromopyruvic acid gives thiazolylhydrazone hydrobromides, which were converted to the free bases.The question of the site of protonation was studied by PMR spectroscopy.The possibility of self-protonation in 4-carboxythiazolylhydrazone crystals is not excluded.The thiazolylhydrazones are brominated in the 5 position.Both cyclization to thiazolyltriazoles and the Chetteueya-Walker reaction are realized in the case of oxidation with lead tetraacetate.
