136265-59-3

Basic information

• Product Name: ethyl 2-[2-(4-methoxybenzylidene)hydrazino]-1,3-thiazole-4-carboxylate
• Synonyms: ethyl 2-[2-(4-methoxybenzylidene)hydrazino]-1,3-thiazole-4-carboxylate
• CAS NO: 136265-59-3
• Molecular Formula: C₁₄H₁₅N₃O₃S
• Molecular Weight: 305.3522
• Mol File: 136265-59-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-[2-(4-methoxybenzylidene)hydrazino]-1,3-thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[2-(4-methoxybenzylidene)hydrazino]-1,3-thiazole-4-carboxylate(136265-59-3)
• EPA Substance Registry System: ethyl 2-[2-(4-methoxybenzylidene)hydrazino]-1,3-thiazole-4-carboxylate(136265-59-3)

Safety Data

• Hazardous Substances Data: 136265-59-3(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 4334-74-1 4-methoxybenzylidene thiosemicarbazone 
• 65868-37-3 ethyl 2-oxo-3-chloropropionate 
• 70-23-5 ethyl Bromopyruvate 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 151558-82-6 2-p-methoxybenzylidenehydrazino-4-carboxy-5-bromothiazole 
• 136265-56-0 2-p-methoxybenzylidenehydrazino-4-carboxythiazole 
• 136265-63-9 1-(4-methoxybenzoyl)-2-acetyl-2-(4-carbethoxy-2-thiazolyl)hydrazine 

Relevant articles and documents

The design, synthesis, and: In vitro trypanocidal and leishmanicidal activities of 1,3-thiazole and 4-thiazolidinone ester derivatives

Chagas and leishmaniasis are both neglected tropical diseases, whose inefficient therapies have made them remain the cause for millions of deaths worldwide. Given this, we synthesized 27 novel 1,3-thiazoles and 4-thiazolidinones using bioisosteric and est

SYNTHESIS AND SOME REACTIONS OF 4-CARBOXY-2-THIAZOLYLHYDRAZONES

The condensation of thiosemicarbazones with bromopyruvic acid gives thiazolylhydrazone hydrobromides, which were converted to the free bases.The question of the site of protonation was studied by PMR spectroscopy.The possibility of self-protonation in 4-carboxythiazolylhydrazone crystals is not excluded.The thiazolylhydrazones are brominated in the 5 position.Both cyclization to thiazolyltriazoles and the Chetteueya-Walker reaction are realized in the case of oxidation with lead tetraacetate.