136265-67-3Relevant academic research and scientific papers
BROMINATION OF 2-THIAZOLYLHYDRAZONES
Usol'tseva, S. V.,Andronnikova, G. P.,Shevyrin, V. A.
, p. 226 - 230 (2007/10/02)
Bromination of the 4-carbethoxy- and 4-carboxy-2-thiazolylhydrazones of aldehydes and ketones occurs principally at the 5 position of the thiazole ring.In the case of aldehyde hydrazones an excess of bromine leads to substitution of the methine hydrogen atom and to intramolecular cyclization of the intermediate halohydrazone to 1,2,4-triazolothiazole.
SYNTHESIS AND SOME REACTIONS OF 4-CARBOXY-2-THIAZOLYLHYDRAZONES
Bredikhina, Z. A.,Buzykin, B. I.,Kitaev, Yu. P.
, p. 427 - 433 (2007/10/02)
The condensation of thiosemicarbazones with bromopyruvic acid gives thiazolylhydrazone hydrobromides, which were converted to the free bases.The question of the site of protonation was studied by PMR spectroscopy.The possibility of self-protonation in 4-carboxythiazolylhydrazone crystals is not excluded.The thiazolylhydrazones are brominated in the 5 position.Both cyclization to thiazolyltriazoles and the Chetteueya-Walker reaction are realized in the case of oxidation with lead tetraacetate.
