1362690-77-4Relevant articles and documents
Effective C5-Arylation of Peptide-Integrated Oxazoles: Almazole D
Oberheide, Ansgar,Arndt, Hans-Dieter
, p. 1132 - 1136 (2020/12/22)
An efficient functionalization approach of oxazoles by using Pd-catalyzed cross-coupling reactions is reported. Oxazolone formation and subsequent sulfamoylation in situ are facilitated by employing N,N-diethylsulfamoyl imidazolium triflate. Cross-couplings provide both oxazole-arenes and oxazole-heteroarenes and were compatible with sensitive and epimerization-prone substrates, as exemplified by the total synthesis of the natural product almazole D. (Figure presented.).
