1362690-77-4Relevant academic research and scientific papers
Effective C5-Arylation of Peptide-Integrated Oxazoles: Almazole D
Oberheide, Ansgar,Arndt, Hans-Dieter
, p. 1132 - 1136 (2020/12/22)
An efficient functionalization approach of oxazoles by using Pd-catalyzed cross-coupling reactions is reported. Oxazolone formation and subsequent sulfamoylation in situ are facilitated by employing N,N-diethylsulfamoyl imidazolium triflate. Cross-couplings provide both oxazole-arenes and oxazole-heteroarenes and were compatible with sensitive and epimerization-prone substrates, as exemplified by the total synthesis of the natural product almazole D. (Figure presented.).
Regioselective synthesis of oxazole derivatives via palladium-catalyzed and copper-mediated cascade oxidative cyclization
Zheng, Jia,Zhang, Min,Huang, Liangbin,Hu, Xiaohan,Wu, Wanqing,Huang, Huawen,Jiang, Huangfeng
supporting information, p. 3609 - 3611 (2014/04/03)
A novel Pd-catalyzed/Cu-mediated oxidative cyclization has been developed for the synthesis of trisubstituted oxazoles, which is thought to proceed through cascade formation of C-N and C-O bonds. In this protocol, four hydrogen atoms were removed and water was used as the oxygen atom source. This journal is the Partner Organisations 2014.
