1362772-09-5Relevant academic research and scientific papers
Novel heterocycles via 2-cyano-N-arylacetamide synthesis with docking studies of novel heterocycles as antimicrobial agents utilizing 2-cyano-N-arylacetamide
Abd El Salam, Hayam A.,Ewies, Ewies F.
, p. 1075 - 1085 (2020/04/17)
2-CYANO-N-arylacetamide reagent is used in a straight forward synthesis of various interesting nitrogenous heterocycles such as iminocoumarine, thiazole, dihydropyridine and imidazole or benzoimidazole. Molecular docking studies are described to show the most active compounds as antimicrobial agents. Also, Biological testing of these compounds for their antimicrobial activities against some strains of Gram bacteria and strains of fungi has been carried out.
Divergent synthesis of benzo[d]thiazoles by PIFA-mediated cyclization of β-oxo thioamides
Huang, Peng,Fu, Xiaolan,Liang, Yongjiu,Zhang, Rui,Dong, Dewen
experimental part, p. 121 - 128 (2012/07/14)
Efficient and divergent synthesis of benzo[d]thiazoles is developed from readily available b-oxo thioamides mediated by hypervalent iodine reagent phenyliodine bis(trifluoroaceate) (PIFA) based on reaction conditions selection, which involves the formation of a radical cation and its subsequent intramolecular cyclization process.
