13664-07-8Relevant academic research and scientific papers
Preparation of pseudo-peptide building blocks with retro-thioamide bond mediated via thiocarbamoyl Meldrum's acid
Janikowska, Karolina,Makowiec, Slawomir,Rachon, Janusz
experimental part, p. 461 - 468 (2012/05/04)
An easy and efficient synthesis of pseudo-tripeptide containing a thiomalonamide moiety was developed. Isothiocyanate derivatives of amino acids react smoothly with 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid) to yield new thiocarbamoyl derivatives of Meldrum's acids. Thermal decomposition of these new derivatives leads to thiocarbamoyl ketenes, which acylate amino acid esters to give pseudo-tripeptides. Copyright
A facile and practical one-pot synthesis of β-oxo thioamides from β-oxo amides and isothiocyanates
Huang, Peng,Xiang, Dexuan,Zhou, Yang,Liang, Yongjiu,Na, Tianhai,Dong, Dewen
experimental part, p. 1797 - 1800 (2010/03/30)
A facile and practical one-pot synthesis of β-oxo thioamides from β-oxo amides has been developed. By treatment with isothiocyanates in ethanol in the presence of potassium carbonate, a series of β-oxo amides was converted, under reflux, in high yields in
