136280-99-4

Upstream product

• 859945-90-7 acetic acid-[2-(2-chloro-benzoyl)-4,5-dimethyl-anilide] 
• 89-98-5 2-chloro-benzaldehyde 
• 95-64-7 4-amino-o-xylene 
• 2198-54-1 N-(3,4-dimethylphenyl)acetamide 
• 609-65-4 o-chlorobenzoyl chloride 

Downstream Products

• 92961-76-7 1-(2-Amino-4,5-dimethyl-phenyl)-1-(2-chlor-phenyl)-aethanol 
• 136281-01-1 methyl 4-(2-chlorophenyl)-1,2-dihydro-6,7-dimethyl-2-oxo-3-quinolinecarboxylate 
• 1026338-74-8 4-(2-Chloro-phenyl)-3-isocyanato-1,6,7-trimethyl-1H-quinolin-2-one 
• 136281-03-3 4-(2-chlorophenyl)-1,2-dihydro-2-oxo-1,6,7-trimethyl-3-quinolinecarboxylic acid 
• 136281-09-9 4-(2-chlorophenyl)-1-ethyl-1,2-dihydro-6,7-dimethyl-2-oxo-3-quinolinecarboxylic acid 
• 136281-02-2 methyl 4-(2-chlorophenyl)-1,2-dihydro-1,6,7-trimethyl-2-oxo-3quinolinecarboxylate 
• 1026905-76-9 4-(2-Chloro-phenyl)-1-ethyl-3-isocyanato-6,7-dimethyl-1H-quinolin-2-one 
• 136281-08-8 4-(2-Chloro-phenyl)-1-ethyl-6,7-dimethyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid methyl ester 
• 882532-25-4 5-(2-chlorophenyl)-1,2-dihydro-3,7,8-trimethyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine 

Relevant academic research and scientific papers

7,8-Disubstituted pyrazolobenzodiazepines

The present invention provides compounds of formula I wherein R1, R2, R3, R4, and R5 are described herein. The invention also provides syntheses for preparation of such compounds and pharmaceutical compositions containing them. The invention further provides methods for inhibiting kinases, in particular CDK2, for inhibiting angiogenesis, and for treating cancers, in particular breast, colon, prostate, and lung cancer.