2198-54-1

Basic information

• Product Name: 3',4'-DIMETHYLACETANILIDE
• Synonyms: 3',4'-DIMETHYLACETANILIDE;3,4-DIMETHYLACETANILIDE;3',4'-Acetoxylidide;3,4-DMA;3’,4’-acetoxylidide;Acetamide, N-(3,4-dimethylphenyl)-;n-(3,4-dimethylphenyl)-acetamid;N-(3,4-Dimethylphenyl)acetamide
• CAS NO: 2198-54-1
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• EINECS: 218-597-3
• Mol File: 2198-54-1.mol
• Article Data: 39

Chemical Properties

• Melting Point: 96-98°C
• Boiling Point: 290.31°C (rough estimate)
• Flash Point: 183.6 °C
• Appearance: /
• Density: 1.0508 (rough estimate)
• Vapor Pressure: 0.000465mmHg at 25°C
• Refractive Index: 1.5400 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 15.13±0.70(Predicted)
• BRN: 387706
• CAS DataBase Reference: 3',4'-DIMETHYLACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-DIMETHYLACETANILIDE(2198-54-1)
• EPA Substance Registry System: 3',4'-DIMETHYLACETANILIDE(2198-54-1)

Safety Data

• Statements: 22
• Safety Statements: 22-36/37-36
• RTECS: AN7500000
• Hazardous Substances Data: 2198-54-1(Hazardous Substances Data)

Usage

Safety Profile

Moderately toxic by ingestion.Questionable carcinogen with experimental tumorigenicdata. When heated to decomposition it emits toxic fumes ofNOx.

InChI:InChI=1/C10H13NO/c1-7-4-5-10(6-8(7)2)11-9(3)12/h4-6H,1-3H3,(H,11,12)

Upstream product

• 108-24-7 acetic anhydride 
• 95-64-7 4-amino-o-xylene 
• 64-19-7 acetic acid 
• 31599-61-8 3,4-dimethyliodobenzene 
• 75-05-8 acetonitrile 
• 91817-69-5 3',4'-dimethylacetophenone oxime 
• 3637-01-2 3,4-dimethylacetophenone 
• 5580-33-6 3,4-dimethylbenzamide 
• 91817-69-5 3,4-Dimethylacetophenon-oxim 
• 67-64-1 acetone 
• 95-47-6 o-xylene 
• 123765-70-8 N-(2-iodo-4,5-dimethylphenyl)acetamide 
• 123-54-6 acetylacetone 
• 79-24-3 Nitroethane 

Downstream Products

• 92246-61-2 4-(2-acetylamino-4,5-dimethyl-phenyl)-4-oxo-butyric acid 
• 860181-61-9 2-(2-acetylamino-4,5-dimethyl-benzoyl)-benzoic acid 
• 860747-78-0 2,5-dibromo-3,4-dimethyl-aniline 
• 106634-67-7 2-amino-4,5-dimethyl acetophenone 
• 720-50-3 acetic acid-(2-chloroacetyl-4,5-dimethyl-anilide) 
• 22058-60-2 N-(3,4-dimethyl-phenyl)-N-methyl-acetamide 
• 22364-28-9 N-(2-bromo-4,5-dimethylphenyl)acetamide 
• 1585-21-3 acetic acid-(2-chloro-4,5-dimethyl-anilide) 
• 103204-69-9 4-acetylamino-2-methylbenzoic acid 
• 857571-00-7 acetic acid-(3,4-dimethyl-5-nitro-anilide) 

Relevant articles and documents

Efficient nitriding reagent and application thereof

The invention discloses an efficient nitriding reagent and application thereof, wherein the nitriding reagent comprises nitrogen oxide, an active agent, a reducing agent and an organic solvent. By applying the nitriding reagent, nitrogen-containing compounds such as amide, nitrile and the like can be produced, and the method is simple in condition, low in waste discharge amount and simple in reaction equipment.

Visible-light-induced Beckmann rearrangement by organic photoredox catalysis

A facile and general strategy for efficient direct conversion of oximes to amides using an inexpensive organic photocatalyst and visible light is described. This radical Beckmann rearrangement can be performed under mild conditions. Various alkyl aryl ketoximes and diaryl ketoximes can be effectively converted into the corresponding amides in excellent yields.

Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles

The Schmidt reaction has been an efficient and widely used synthetic approach to amides and nitriles since its discovery in 1923. However, its application often entails the use of volatile, potentially explosive, and highly toxic azide reagents. Here, we report a sequence whereby triflic anhydride and formic and acetic acids activate the bulk chemical nitromethane to serve as a nitrogen donor in place of azides in Schmidt-like reactions. This protocol further expands the substrate scope to alkynes and simple alkyl benzenes for the preparation of amides and nitriles.