136281-11-3Relevant academic research and scientific papers
NEW ARYL-QUINOLINE DERIVATIVES
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Page/Page column 53, (2013/05/22)
The invention provides novel compounds having the general formula (I), wherein R1, R2, R3, R4 R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds.
ARYL-QUINOLINE DERIVATIVES
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Paragraph 0368; 0369; 0370, (2013/05/21)
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.
Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent Acyl-CoA: Cholesterol acyltransferase inhibitors
Tawada,Natsugari,Ishikawa,Sugiyama,Ikeda,Meguro
, p. 616 - 625 (2007/10/02)
Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA: cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC50 values at the 10-8 to 10-9 M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.
Quinoline derivatives, their production and use
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, (2008/06/13)
A quinoline derivative of the formula (I): STR1 wherein each phenyl ring of A, B and C can have one or more substituents, X is STR2 (R1 is a hydrogen atom or a lower alkyl group) or STR3 (R2 is a lower alkyl group or a lower alkoxy g
