136281-12-4Relevant academic research and scientific papers
Quinoline-3-carboxylates as potential antibacterial agents
Krishnakumar,Khan, Fazlur-Rahman Nawaz,Mandal, Badal Kumar,Mitta, Sukanya,Dhasamandha, Ramu,Govindan, Vindhya Nanu
, p. 1819 - 1826 (2013/02/22)
The ethyl-2-chloroquinoline-3-carboxylates, 4, were achieved fromo-aminobenzophenones in two steps. i.e. initially, the ethyl-2-oxoquinoline- 3-carboxylates, 3, were obtained by base-catalyzed Friedlander condensations of o-aminobenzophenones, 1, and diethylmalonate, 2. The 2-chloroquinoline-3- carboxylates, 4, were then obtained by the reaction with POCl3 in good yields. The chemical structures were confirmed by FTIR, mass and 1H-NMR spectroscopic techniques. All the synthesized compounds were tested for their in vitro antibacterial activity against Bacillus subtilis and Vibrio cholera and found to possess moderate activity. Springer Science+Business Media B.V. 2012.
Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent Acyl-CoA: Cholesterol acyltransferase inhibitors
Tawada,Natsugari,Ishikawa,Sugiyama,Ikeda,Meguro
, p. 616 - 625 (2007/10/02)
Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA: cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC50 values at the 10-8 to 10-9 M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.
Quinoline derivatives, their production and use
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, (2008/06/13)
A quinoline derivative of the formula (I): STR1 wherein each phenyl ring of A, B and C can have one or more substituents, X is STR2 (R1 is a hydrogen atom or a lower alkyl group) or STR3 (R2 is a lower alkyl group or a lower alkoxy g
