1362860-75-0

Upstream product

• 1362860-49-8 2-((2S,4S)-2-cyclohexyl-1,3-dioxolan-4-yl)-1-phenylethanone 
• 156386-82-2 trans-γ-3-benzoylprop-2-en-1-ol 
• 2043-61-0 cyclohexanecarbaldehyde 
• 58509-75-4 4-hydroxy-1-phenylbut-2-en-1-one 

Downstream Products

• 159974-69-3 (2S,4R)-4-phenyl-1,2,4-butanetriol 

Relevant academic research and scientific papers

Asymmetric cycloetherifications by bifunctional aminothiourea catalysts: The importance of hydrogen bonding

Chiral oxacyclic frameworks are prevalent in many natural products and bioactive compounds. In addition, a number of them are important synthetic intermediates. Thus, the synthesis of such structures is a significant goal in the field of organic chemistry. However, the development of catalytic asymmetric cycloetherification for the straightforward synthesis of these compounds remains a challenge. In this study, we propose the use of aminothiourea catalysis as an effective way to accomplish such a challenge. The asymmetric synthesis of chiral oxygen heterocycles, including tetrahydrofurans, tetrahydropyrans, and 1,3-dioxolanes, is demonstrated herein using intramolecular oxy-Michael addition mediated by bifunctional aminothiourea catalysts. Georg Thieme Verlag Stuttgart · New York.

Asymmetric synthesis of 1,3-dioxolanes by organocatalytic formal [3 + 2] cycloaddition via hemiacetal intermediates

A novel asymmetric formal [3 + 2] cycloaddition reaction for the synthesis of 1,3-dioxolanes using cinchona-alkaloid-thiourea-based bifunctional organocatalysts is reported. The reaction proceeds via the formation of hemiacetal intermediates between γ-hyd