159974-69-3

Upstream product

• 1362860-49-8 2-((2S,4S)-2-cyclohexyl-1,3-dioxolan-4-yl)-1-phenylethanone 
• 156386-82-2 trans-γ-3-benzoylprop-2-en-1-ol 
• 1362860-75-0 (R)-2-((2S,4S)-2-cyclohexyl-1,3-dioxolan-4-yl)-1-phenylethanol 
• 272442-18-9 (S)-5-Methoxymethyl-3-phenyl-4,5-dihydro-isoxazole 
• 124154-34-3 (S)-5-(Hydroxymethyl)-Δ²-isoxazoline 
• 100-52-7 benzaldehyde 
• 159974-67-1 (S)-3,4-dihydroxy-1-phenylbutan-1-one 
• 932-90-1 Benzaldoxime 
• 1569-94-4 (3-phenyl-4,5-dihydro-isoxazol-5-yl)-methanol 

Relevant academic research and scientific papers

Chiral epoxides as a source of chiral β-oxidofunctionalised organolithium compounds: Reaction with electrophiles

The reductive opening of chiral epoxides 1, 4, 7 and 11 with lithium powder and a catalytic amount of DTBB (5 mol %) in THF at -78°C, followed by treatment with different electrophiles [Bu(t)CHO, PhCHO, (CH2)5CO, PhCOMe, CO2/su

Asymmetric cycloetherifications by bifunctional aminothiourea catalysts: The importance of hydrogen bonding

Chiral oxacyclic frameworks are prevalent in many natural products and bioactive compounds. In addition, a number of them are important synthetic intermediates. Thus, the synthesis of such structures is a significant goal in the field of organic chemistry. However, the development of catalytic asymmetric cycloetherification for the straightforward synthesis of these compounds remains a challenge. In this study, we propose the use of aminothiourea catalysis as an effective way to accomplish such a challenge. The asymmetric synthesis of chiral oxygen heterocycles, including tetrahydrofurans, tetrahydropyrans, and 1,3-dioxolanes, is demonstrated herein using intramolecular oxy-Michael addition mediated by bifunctional aminothiourea catalysts. Georg Thieme Verlag Stuttgart · New York.

Asymmetric synthesis of 1,3-dioxolanes by organocatalytic formal [3 + 2] cycloaddition via hemiacetal intermediates

A novel asymmetric formal [3 + 2] cycloaddition reaction for the synthesis of 1,3-dioxolanes using cinchona-alkaloid-thiourea-based bifunctional organocatalysts is reported. The reaction proceeds via the formation of hemiacetal intermediates between γ-hyd

Synthesis of a bifunctional 2,4-dihydroxy five-carbon synthon. Enantiomerically pure Δ2-isoxazolines by chromatographic resolution

Chromatography on cellulose triacetate allows the separation of (R)- and (S)-4,5-dihydro-3-phenyl-5-isoxazolemethanol in 100% ee. Reductive ring cleavage, diastereoselective reduction of the 3-hydroxy ketones thus obtained, and oxidation of the phenyl rin