136291-81-1

Upstream product

• 1208-40-8 4-chloro-3-sulfamoylbenzoic acid methyl ester 
• 107-15-3 ethylenediamine 

Downstream Products

• 136291-88-8 CART-VI 
• 136291-87-7 4-Chloro-N-(2-{2-hydroxy-3-[1-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-8-yl)-eth-(E)-ylideneaminooxy]-propylamino}-ethyl)-3-sulfamoyl-benzamide 
• 136291-85-5 4-Chloro-N-(2-{2-hydroxy-3-[1-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl)-eth-(E)-ylideneaminooxy]-propylamino}-ethyl)-3-sulfamoyl-benzamide 
• 136291-86-6 4-Chloro-N-(2-{2-hydroxy-3-[1-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-7-yl)-eth-(E)-ylideneaminooxy]-propylamino}-ethyl)-3-sulfamoyl-benzamide 
• 136310-56-0 4-Chloro-N-(2-{2-hydroxy-3-[3-oxo-3,4,6,7-tetrahydro-2H,5H-benzo[1,4]thiazin-(8E)-ylideneaminooxy]-propylamino}-ethyl)-3-sulfamoyl-benzamide 
• 136291-84-4 3-<<2-(4-chloro-3-sulfamoylbenzamido)ethyl>amino>-1-<(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-8-yl)oxy>propan-2-ol 
• 136291-82-2 4-Chloro-N-{2-[2-hydroxy-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yloxy)-propylamino]-ethyl}-3-sulfamoyl-benzamide 
• 136291-83-3 4-Chloro-N-{2-[2-hydroxy-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-7-yloxy)-propylamino]-ethyl}-3-sulfamoyl-benzamide 
• 136291-89-9 4-Chloro-N-{2-[2-hydroxy-3-(naphthalen-1-yloxy)-propylamino]-ethyl}-3-sulfamoyl-benzamide 

Relevant academic research and scientific papers

SOME NEW ANALOGUES OF VERAPAMIL AND MEPAMIL. SYNTHESIS AND BASIC PHARMACOLOGICAL PROPERTIES

Some new analogues of verapamil (Ia) and mepamil (Ib), calcium antagonists of arylkylamine type, were synthesized and screened for cardiovascular activities.The basic structure was modified a) on the phenyl ring, attached to the quaternary carbon, b) on the alkyl group, attached to the quaternary carbon and c) on the alkylamino group, attached in position 3 to the n-propyl fragment.Except of 2-(2-chlorophenyl)-2-isopropyl-5-(N-methylhomoveratrylamino)valeronitrile (VIa), all the synthesized compounds exhibited lower hypotensive activity, than the mother compound, verapamil.

Symbiotic approach to drug design: N-propanolamine derivatives as β-adrenergic blocking agents with diuretic activity

A series of oxypropanolamines and iminoxypropanolamines, in which the aminic substituent was the 2-(4-chloro-3-sulfamoylbenzamido)-ethyl group, were synthesized as potential β-blocker/diuretic agents.All of these compounds were tested for β1-ad